Detailed information of TA system TA221622

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 932475..932889
• Replicon: chromosome
• Accession: NZ_CP085804
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Leafeon

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: M7RBD3
• Locus tag: LJF49_RS04305
• Protein ID: WP_000994230.1
• Coordinates: 932475..932732 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	932557..932889 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF49_RS04290	928086..928592	+	507	Protein_822	phage late control D family protein	-
LJF49_RS04295	928592..931966	+	3375	Protein_823	RHS domain-containing protein	-
LJF49_RS04300	931963..932409	+	447	WP_000171102.1	hypothetical protein	-
LJF49_RS04305	932475..932732	-	258	WP_000994230.1	SymE family type I addiction module toxin	Toxin
-	932557..932889	+	333	-	-	Antitoxin
LJF49_RS04310	933067..933300	+	234	WP_124084119.1	hypothetical protein	-
LJF49_RS04315	933858..934175	+	318	WP_001751277.1	hypothetical protein	-
LJF49_RS04320	934172..934639	+	468	WP_000828182.1	sugar tyrosine-protein kinase	-
LJF49_RS04325	934956..935234	+	279	WP_012543321.1	hypothetical protein	-
LJF49_RS04330	935301..935615	-	315	WP_072100769.1	SymE family type I addiction module toxin	-
LJF49_RS04335	935668..935877	+	210	WP_001676010.1	hypothetical protein	-
LJF49_RS04340	935798..936368	+	571	Protein_832	integrase core domain-containing protein	-
LJF49_RS04345	937131..937628	+	498	WP_016695185.1	Saf-pilin pilus formation protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	927171..946262	19091
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_003197 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 IS/Tn TA010105 341179..341460 0.009 View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 IS/Tn TA010103 340656..340937 0.009 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S IS/Tn TA026042 341863..342144 0.009	flank	IS/Tn	-	-	936090..936368	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 9.5519

>T221622 WP_000994230.1 NZ_CP085804:c932732-932475 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Nucleotide

• Length: 258 bp

>T221622 NZ_CP117556:c1981311-1980913 [Escherichia albertii]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCTTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT221622 NZ_CP085804:932557-932889 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A656IER2

Antitoxin