37567

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3747370..3747802 Replicon chromosome
Accession NZ_AP023317
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4681

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K5693_RS18540 Protein ID WP_000994224.1
Coordinates 3747527..3747802 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3747370..3747792 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5693_RS18510 3743588..3744325 - 738 WP_001535430.1 pili assembly chaperone SafB -
K5693_RS18515 3744409..3744921 - 513 WP_077248260.1 pilus assembly protein -
K5693_RS18520 3745671..3746375 - 705 Protein_3639 integrase core domain-containing protein -
K5693_RS18525 3746428..3746676 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K5693_RS18530 3746778..3747086 - 309 WP_010988969.1 hypothetical protein -
K5693_RS18535 3747169..3747342 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3747370..3747792 - 423 - - Antitoxin
K5693_RS18540 3747527..3747802 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K5693_RS18545 3747855..3748292 - 438 WP_000943620.1 immunity 26/phosphotriesterase HocA family protein -
K5693_RS18550 3748855..3749301 - 447 WP_000935097.1 protein SciX -
K5693_RS18555 3749295..3750164 - 870 Protein_3646 polymorphic toxin type 47 domain-containing protein -
K5693_RS18560 3750228..3750491 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3736518..3750491 13973
flank IS/Tn - - 3745671..3745952 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T37567 WP_000994224.1 NZ_AP023317:3747527-3747802 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T37567 NZ_AP023317:3747527-3747802 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT37567 NZ_AP023317:c3747792-3747370 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References