146578

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3795769..3796201 Replicon chromosome
Accession NZ_CP047544
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10250

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN29_RS18895 Protein ID WP_000994224.1
Coordinates 3795926..3796201 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3795769..3796191 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN29_RS18865 3791987..3792724 - 738 WP_001535430.1 pili assembly chaperone SafB -
DXN29_RS18870 3792808..3793320 - 513 WP_077248260.1 pilus assembly protein -
DXN29_RS18875 3794070..3794774 - 705 Protein_3699 integrase core domain-containing protein -
DXN29_RS18880 3794827..3795075 + 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN29_RS18885 3795177..3795485 - 309 WP_010988969.1 hypothetical protein -
DXN29_RS18890 3795568..3795741 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3795769..3796191 - 423 - - Antitoxin
DXN29_RS18895 3795926..3796201 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
DXN29_RS18900 3796254..3796691 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN29_RS18905 3797254..3797700 - 447 WP_000935097.1 protein SciX -
DXN29_RS18910 3797694..3798563 - 870 Protein_3706 polymorphic toxin type 47 domain-containing protein -
DXN29_RS18915 3798627..3798890 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3794070..3794351 281
- inside Prophage - gtrA / gtrB / gmhA/lpcA 3685252..3805656 120404


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146578 WP_000994224.1 NZ_CP047544:3795926-3796201 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146578 NZ_CP062763:1093267-1093602 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 423 bp

>AT146578 NZ_CP047544:c3796191-3795769 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References