270683

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3736762..3737176 Replicon chromosome
Accession NZ_CP117346
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM104

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQP85_RS18605 Protein ID WP_000994230.1
Coordinates 3736919..3737176 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3736762..3737094 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP85_RS18565 3732023..3732475 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
PQP85_RS18570 3733284..3733854 - 571 Protein_3636 integrase core domain-containing protein -
PQP85_RS18575 3733775..3733984 - 210 WP_001676010.1 hypothetical protein -
PQP85_RS18580 3734037..3734351 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQP85_RS18585 3734418..3734696 - 279 WP_012543321.1 hypothetical protein -
PQP85_RS18590 3735012..3735479 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQP85_RS18595 3735476..3735793 - 318 WP_001751277.1 hypothetical protein -
PQP85_RS18600 3736351..3736584 - 234 WP_124084119.1 hypothetical protein -
- 3736762..3737094 - 333 - - Antitoxin
PQP85_RS18605 3736919..3737176 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQP85_RS18610 3737242..3737688 - 447 WP_000171102.1 hypothetical protein -
PQP85_RS18615 3737685..3740507 - 2823 Protein_3645 RHS repeat-associated core domain-containing protein -
PQP85_RS18620 3740498..3740764 + 267 WP_223151220.1 SymE family type I addiction module toxin -
PQP85_RS18625 3740882..3741220 - 339 WP_000201550.1 hypothetical protein -
PQP85_RS18630 3741242..3741562 - 321 WP_016695071.1 HNH endonuclease -
PQP85_RS18635 3741620..3741903 - 284 Protein_3649 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3724128..3742456 18328
flank IS/Tn - - 3733284..3733562 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270683 WP_000994230.1 NZ_CP117346:3736919-3737176 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270683 NZ_CP117346:c3737094-3736762 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References