280822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3602298..3602712 Replicon chromosome
Accession NZ_CP124522
Organism Salmonella enterica strain PNUSAS118467

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag QJS74_RS17735 Protein ID WP_000994230.1
Coordinates 3602455..3602712 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3602298..3602630 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS74_RS17695 3597559..3598056 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
QJS74_RS17700 3598819..3599389 - 571 Protein_3461 integrase core domain-containing protein -
QJS74_RS17705 3599310..3599519 - 210 WP_001676010.1 hypothetical protein -
QJS74_RS17710 3599572..3599886 + 315 WP_072100769.1 SymE family type I addiction module toxin -
QJS74_RS17715 3599953..3600231 - 279 WP_012543321.1 hypothetical protein -
QJS74_RS17720 3600548..3601015 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
QJS74_RS17725 3601012..3601329 - 318 WP_001751277.1 hypothetical protein -
QJS74_RS17730 3601887..3602120 - 234 WP_124084119.1 hypothetical protein -
- 3602298..3602630 - 333 - - Antitoxin
QJS74_RS17735 3602455..3602712 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
QJS74_RS17740 3602778..3603224 - 447 WP_000171102.1 hypothetical protein -
QJS74_RS17745 3603221..3606595 - 3375 Protein_3470 RHS repeat-associated core domain-containing protein -
QJS74_RS17750 3606595..3607101 - 507 Protein_3471 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3591990..3606517 14527
flank IS/Tn - - 3598819..3599097 278
- inside Genomic island - - 3589663..3603224 13561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T280822 WP_000994230.1 NZ_CP124522:3602455-3602712 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT280822 NZ_CP124522:c3602630-3602298 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References