231045

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 994426..994858 Replicon chromosome
Accession NZ_CP090533
Organism Salmonella enterica strain 2017005-SE

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag L0F61_RS04700 Protein ID WP_000994224.1
Coordinates 994426..994701 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 994436..994858 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F61_RS04680 991737..992000 + 264 WP_000932531.1 hypothetical protein -
L0F61_RS04685 992064..992933 + 870 Protein_909 polymorphic toxin type 47 domain-containing protein -
L0F61_RS04690 992927..993373 + 447 WP_000935097.1 protein SciX -
L0F61_RS04695 993936..994373 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
L0F61_RS04700 994426..994701 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 994436..994858 + 423 - - Antitoxin
L0F61_RS04705 994943..995059 + 117 WP_227457392.1 hypothetical protein -
L0F61_RS04710 995142..995450 + 309 WP_010988969.1 hypothetical protein -
L0F61_RS04715 995552..995800 - 249 WP_001738030.1 SymE family type I addiction module toxin -
L0F61_RS04720 995853..996557 + 705 Protein_916 integrase core domain-containing protein -
L0F61_RS04725 997307..997819 + 513 WP_077248260.1 pilus assembly protein -
L0F61_RS04730 997903..998640 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 992160..1006448 14288
flank IS/Tn - - 996276..996557 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T231045 WP_000994224.1 NZ_CP090533:c994701-994426 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T231045 NZ_CP125899:c2082468-2082259 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 423 bp

>AT231045 NZ_CP090533:994436-994858 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References