247628

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3671093..3671525 Replicon chromosome
Accession NZ_CP098438
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag M9193_RS17930 Protein ID WP_000994224.1
Coordinates 3671250..3671525 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3671093..3671515 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9193_RS17900 3667311..3668048 - 738 WP_001535430.1 pili assembly chaperone SafB -
M9193_RS17905 3668132..3668644 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
M9193_RS17910 3669394..3670098 - 705 Protein_3503 integrase core domain-containing protein -
M9193_RS17915 3670151..3670399 + 249 WP_001738030.1 SymE family type I addiction module toxin -
M9193_RS17920 3670501..3670809 - 309 WP_010988969.1 hypothetical protein -
M9193_RS17925 3670892..3671008 - 117 WP_227457392.1 hypothetical protein -
- 3671093..3671515 - 423 - - Antitoxin
M9193_RS17930 3671250..3671525 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
M9193_RS17935 3671578..3672015 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
M9193_RS17940 3672578..3673024 - 447 WP_000935097.1 protein SciX -
M9193_RS17945 3673018..3673887 - 870 Protein_3510 polymorphic toxin type 47 domain-containing protein -
M9193_RS17950 3673951..3674214 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3662565..3674214 11649
flank IS/Tn - - 3669394..3669675 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T247628 WP_000994224.1 NZ_CP098438:3671250-3671525 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT247628 NZ_CP098438:c3671515-3671093 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References