212661

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3699028..3699460 Replicon chromosome
Accession NZ_CP081187
Organism Salmonella enterica strain sg1722-1

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K4F82_RS18115 Protein ID WP_000994224.1
Coordinates 3699185..3699460 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3699028..3699450 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F82_RS18085 3695247..3695984 - 738 WP_001535430.1 pili assembly chaperone SafB -
K4F82_RS18090 3696068..3696580 - 513 WP_077248260.1 pilus assembly protein -
K4F82_RS18095 3697329..3698033 - 705 Protein_3556 integrase core domain-containing protein -
K4F82_RS18100 3698086..3698334 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K4F82_RS18105 3698436..3698744 - 309 WP_010988969.1 hypothetical protein -
K4F82_RS24365 3698827..3698943 - 117 WP_227457392.1 hypothetical protein -
- 3699028..3699450 - 423 - - Antitoxin
K4F82_RS18115 3699185..3699460 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K4F82_RS18120 3699513..3699950 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
K4F82_RS18125 3700513..3700959 - 447 WP_000935097.1 protein SciX -
K4F82_RS18130 3700953..3701822 - 870 Protein_3563 polymorphic toxin type 47 domain-containing protein -
K4F82_RS18135 3701886..3702149 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3690501..3702149 11648
flank IS/Tn - - 3697329..3697610 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T212661 WP_000994224.1 NZ_CP081187:3699185-3699460 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T212661 NZ_CP107312:c2674700-2674317 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 423 bp

>AT212661 NZ_CP081187:c3699450-3699028 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References