222007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 730449..730863 Replicon chromosome
Accession NZ_CP085821
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF63_RS03365 Protein ID WP_000994230.1
Coordinates 730449..730706 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 730531..730863 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF63_RS03350 726060..726566 + 507 Protein_650 phage late control D family protein -
LJF63_RS03355 726566..729940 + 3375 Protein_651 RHS domain-containing protein -
LJF63_RS03360 729937..730383 + 447 WP_000171102.1 hypothetical protein -
LJF63_RS03365 730449..730706 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 730531..730863 + 333 - - Antitoxin
LJF63_RS03370 731041..731274 + 234 WP_124084119.1 hypothetical protein -
LJF63_RS03375 731832..732149 + 318 WP_001751277.1 hypothetical protein -
LJF63_RS03380 732146..732613 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF63_RS03385 732930..733208 + 279 WP_012543321.1 hypothetical protein -
LJF63_RS03390 733275..733589 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF63_RS03395 733642..733851 + 210 WP_001676010.1 hypothetical protein -
LJF63_RS03400 733772..734342 + 571 Protein_660 integrase core domain-containing protein -
LJF63_RS03405 735105..735602 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 725145..744236 19091
flank IS/Tn - - 734064..734342 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T222007 WP_000994230.1 NZ_CP085821:c730706-730449 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T222007 NZ_CP117654:c2616638-2616483 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGACCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 333 bp

>AT222007 NZ_CP085821:730531-730863 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References