257786

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3712424..3712856 Replicon chromosome
Accession NZ_CP104366
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag N4533_RS18355 Protein ID WP_000994224.1
Coordinates 3712581..3712856 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3712424..3712846 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4533_RS18325 3708642..3709379 - 738 WP_001535430.1 pili assembly chaperone SafB -
N4533_RS18330 3709463..3709975 - 513 WP_010988970.1 Saf-pilin pilus formation protein SafA -
N4533_RS18335 3710725..3711429 - 705 Protein_3586 integrase core domain-containing protein -
N4533_RS18340 3711482..3711730 + 249 WP_001738030.1 SymE family type I addiction module toxin -
N4533_RS18345 3711832..3712140 - 309 WP_010988969.1 hypothetical protein -
N4533_RS18350 3712223..3712339 - 117 WP_227457392.1 hypothetical protein -
- 3712424..3712846 - 423 - - Antitoxin
N4533_RS18355 3712581..3712856 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
N4533_RS18360 3712909..3713346 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
N4533_RS18365 3713909..3714355 - 447 WP_000935097.1 protein SciX -
N4533_RS18370 3714349..3715218 - 870 Protein_3593 polymorphic toxin type 47 domain-containing protein -
N4533_RS18375 3715282..3715545 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3701572..3715545 13973
flank IS/Tn - - 3710725..3711006 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T257786 WP_000994224.1 NZ_CP104366:3712581-3712856 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT257786 NZ_CP104366:c3712846-3712424 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References