Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3747072..3747504 Replicon chromosome
Accession NZ_AP023304
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4551

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K5676_RS18550 Protein ID WP_000994224.1
Coordinates 3747229..3747504 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3747072..3747494 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5676_RS18520 3743290..3744027 - 738 WP_001535430.1 pili assembly chaperone SafB -
K5676_RS18525 3744111..3744623 - 513 WP_077248260.1 pilus assembly protein -
K5676_RS18530 3745373..3746077 - 705 Protein_3640 integrase core domain-containing protein -
K5676_RS18535 3746130..3746378 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K5676_RS18540 3746480..3746788 - 309 WP_010988969.1 hypothetical protein -
K5676_RS18545 3746871..3747044 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3747072..3747494 - 423 - - Antitoxin
K5676_RS18550 3747229..3747504 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K5676_RS18555 3747557..3747994 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
K5676_RS18560 3748557..3749003 - 447 WP_000935097.1 protein SciX -
K5676_RS18565 3748997..3749866 - 870 Protein_3647 polymorphic toxin type 47 domain-containing protein -
K5676_RS18570 3749930..3750193 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3736220..3750193 13973
flank IS/Tn - - 3745373..3745654 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T37406 WP_000994224.1 NZ_AP023304:3747229-3747504 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T37406 NZ_AP023304:3747229-3747504 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT37406 NZ_AP023304:c3747494-3747072 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References