221661

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3944823..3945237 Replicon chromosome
Accession NZ_CP085805
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Azumarill

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF48_RS19430 Protein ID WP_000994230.1
Coordinates 3944980..3945237 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3944823..3945155 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF48_RS19390 3940084..3940581 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LJF48_RS19395 3941344..3941914 - 571 Protein_3780 integrase core domain-containing protein -
LJF48_RS19400 3941835..3942044 - 210 WP_001676010.1 hypothetical protein -
LJF48_RS19405 3942097..3942411 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF48_RS19410 3942478..3942756 - 279 WP_012543321.1 hypothetical protein -
LJF48_RS19415 3943073..3943540 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF48_RS19420 3943537..3943854 - 318 WP_001751277.1 hypothetical protein -
LJF48_RS19425 3944412..3944645 - 234 WP_124084119.1 hypothetical protein -
- 3944823..3945155 - 333 - - Antitoxin
LJF48_RS19430 3944980..3945237 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LJF48_RS19435 3945303..3945749 - 447 WP_000171102.1 hypothetical protein -
LJF48_RS19440 3945746..3949120 - 3375 Protein_3789 RHS domain-containing protein -
LJF48_RS19445 3949120..3949626 - 507 Protein_3790 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3934515..3949042 14527
flank IS/Tn - - 3941344..3941622 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221661 WP_000994230.1 NZ_CP085805:3944980-3945237 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221661 NZ_CP117562:1835529-1835843 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAATTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 333 bp

>AT221661 NZ_CP085805:c3945155-3944823 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References