266018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3623802..3624234 Replicon chromosome
Accession NZ_CP113541
Organism Salmonella enterica strain CHC

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag OXV05_RS17640 Protein ID WP_000994224.1
Coordinates 3623959..3624234 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3623802..3624224 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV05_RS17610 3620020..3620757 - 738 WP_001535430.1 pili assembly chaperone SafB -
OXV05_RS17615 3620841..3621353 - 513 WP_077248260.1 pilus assembly protein -
OXV05_RS17620 3622103..3622807 - 705 Protein_3445 integrase core domain-containing protein -
OXV05_RS17625 3622860..3623108 + 249 WP_001738030.1 SymE family type I addiction module toxin -
OXV05_RS17630 3623210..3623518 - 309 WP_010988969.1 hypothetical protein -
OXV05_RS17635 3623601..3623717 - 117 WP_227457392.1 hypothetical protein -
- 3623802..3624224 - 423 - - Antitoxin
OXV05_RS17640 3623959..3624234 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
OXV05_RS17645 3624287..3624724 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
OXV05_RS17650 3625287..3625733 - 447 WP_000935097.1 protein SciX -
OXV05_RS17655 3625727..3626596 - 870 Protein_3452 polymorphic toxin type 47 domain-containing protein -
OXV05_RS17660 3626660..3626923 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3615274..3626923 11649
flank IS/Tn - - 3622103..3622384 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T266018 WP_000994224.1 NZ_CP113541:3623959-3624234 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT266018 NZ_CP113541:c3624224-3623802 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References