251228

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3642080..3642494 Replicon chromosome
Accession NZ_CP100724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag NL714_RS18010 Protein ID WP_000994230.1
Coordinates 3642237..3642494 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3642080..3642412 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL714_RS17970 3637341..3637838 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
NL714_RS17975 3638601..3639171 - 571 Protein_3516 integrase core domain-containing protein -
NL714_RS17980 3639092..3639301 - 210 WP_001676010.1 hypothetical protein -
NL714_RS17985 3639354..3639668 + 315 WP_072100769.1 SymE family type I addiction module toxin -
NL714_RS17990 3639735..3640013 - 279 WP_012543321.1 hypothetical protein -
NL714_RS17995 3640330..3640797 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
NL714_RS18000 3640794..3641111 - 318 WP_001751277.1 hypothetical protein -
NL714_RS18005 3641669..3641902 - 234 WP_124084119.1 hypothetical protein -
- 3642080..3642412 - 333 - - Antitoxin
NL714_RS18010 3642237..3642494 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
NL714_RS18015 3642560..3643006 - 447 WP_000171102.1 hypothetical protein -
NL714_RS18020 3643003..3646377 - 3375 Protein_3525 RHS domain-containing protein -
NL714_RS18025 3646377..3646883 - 507 Protein_3526 phage late control D family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3629445..3646299 16854
flank IS/Tn - - 3638601..3638879 278
- inside Genomic island - - 3631772..3646299 14527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-56)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T251228 WP_000994230.1 NZ_CP100724:3642237-3642494 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp


Antitoxin


Download         Length: 333 bp

>AT251228 NZ_CP100724:c3642412-3642080 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A656IER2


Antitoxin

Download structure file

References