226828

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3581086..3581500 Replicon chromosome
Accession NZ_CP088142
Organism Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LRM93_RS17575 Protein ID WP_000994230.1
Coordinates 3581243..3581500 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3581086..3581418 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM93_RS17535 3576347..3576844 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LRM93_RS17540 3577607..3578177 - 571 Protein_3435 integrase core domain-containing protein -
LRM93_RS17545 3578098..3578307 - 210 WP_001676010.1 hypothetical protein -
LRM93_RS17550 3578360..3578674 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LRM93_RS17555 3578741..3579019 - 279 WP_012543321.1 hypothetical protein -
LRM93_RS17560 3579336..3579803 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LRM93_RS17565 3579800..3580117 - 318 WP_001751277.1 hypothetical protein -
LRM93_RS17570 3580675..3580908 - 234 WP_124084119.1 hypothetical protein -
- 3581086..3581418 - 333 - - Antitoxin
LRM93_RS17575 3581243..3581500 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LRM93_RS17580 3581566..3582012 - 447 WP_000171102.1 hypothetical protein -
LRM93_RS17585 3582009..3585383 - 3375 Protein_3444 RHS repeat-associated core domain-containing protein -
LRM93_RS17590 3585383..3585889 - 507 Protein_3445 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3570779..3585305 14526
flank IS/Tn - - 3577607..3577885 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T226828 WP_000994230.1 NZ_CP088142:3581243-3581500 [Salmonella enterica subsp. enterica serovar Gallinarum]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T226828 NZ_CP122634:c2213165-2212971 [Escherichia coli]
ATGCGGTATGAAAAAGTCAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
CGCGAAGTGTAACGGATGCGAATCCCGAACCGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 333 bp

>AT226828 NZ_CP088142:c3581418-3581086 [Salmonella enterica subsp. enterica serovar Gallinarum]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References