252065

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3765607..3766039 Replicon chromosome
Accession NZ_CP101382
Organism Salmonella enterica strain SC2017030

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NMU36_RS18675 Protein ID WP_000994224.1
Coordinates 3765764..3766039 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3765607..3766029 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU36_RS18645 3761825..3762562 - 738 WP_001535430.1 pili assembly chaperone SafB -
NMU36_RS18650 3762646..3763158 - 513 WP_077248260.1 pilus assembly protein -
NMU36_RS18655 3763908..3764612 - 705 Protein_3650 integrase core domain-containing protein -
NMU36_RS18660 3764665..3764913 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NMU36_RS18665 3765015..3765323 - 309 WP_010988969.1 hypothetical protein -
NMU36_RS18670 3765406..3765522 - 117 WP_227457392.1 hypothetical protein -
- 3765607..3766029 - 423 - - Antitoxin
NMU36_RS18675 3765764..3766039 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NMU36_RS18680 3766092..3766529 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NMU36_RS18685 3767092..3767538 - 447 WP_000935097.1 protein SciX -
NMU36_RS18690 3767532..3768401 - 870 Protein_3657 polymorphic toxin type 47 domain-containing protein -
NMU36_RS18695 3768465..3768728 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3754755..3768728 13973
flank IS/Tn - - 3763908..3764189 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T252065 WP_000994224.1 NZ_CP101382:3765764-3766039 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT252065 NZ_CP101382:c3766029-3765607 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References