270816

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3736729..3737143 Replicon chromosome
Accession NZ_CP117362
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM092

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQQ00_RS18605 Protein ID WP_000994230.1
Coordinates 3736886..3737143 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3736729..3737061 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ00_RS18565 3731990..3732442 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
PQQ00_RS18570 3733251..3733821 - 571 Protein_3636 integrase core domain-containing protein -
PQQ00_RS18575 3733742..3733951 - 210 WP_001676010.1 hypothetical protein -
PQQ00_RS18580 3734004..3734318 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQQ00_RS18585 3734385..3734663 - 279 WP_012543321.1 hypothetical protein -
PQQ00_RS18590 3734979..3735446 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQQ00_RS18595 3735443..3735760 - 318 WP_001751277.1 hypothetical protein -
PQQ00_RS18600 3736318..3736551 - 234 WP_124084119.1 hypothetical protein -
- 3736729..3737061 - 333 - - Antitoxin
PQQ00_RS18605 3736886..3737143 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQQ00_RS18610 3737209..3737655 - 447 WP_000171102.1 hypothetical protein -
PQQ00_RS18615 3737652..3740474 - 2823 Protein_3645 RHS repeat-associated core domain-containing protein -
PQQ00_RS18620 3740522..3740731 + 210 WP_001675680.1 SymE family type I addiction module toxin -
PQQ00_RS18625 3740849..3741187 - 339 WP_000201550.1 hypothetical protein -
PQQ00_RS18630 3741209..3741529 - 321 WP_016695071.1 HNH endonuclease -
PQQ00_RS18635 3741587..3741870 - 284 Protein_3649 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3724096..3742423 18327
flank IS/Tn - - 3733251..3733529 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270816 WP_000994230.1 NZ_CP117362:3736886-3737143 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270816 NZ_CP117362:c3737061-3736729 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References