146373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3770860..3771292 Replicon chromosome
Accession NZ_CP047525
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11077

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN14_RS18785 Protein ID WP_000994224.1
Coordinates 3771017..3771292 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3770860..3771282 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN14_RS18755 3767078..3767815 - 738 WP_001535430.1 pili assembly chaperone SafB -
DXN14_RS18760 3767899..3768411 - 513 WP_077248260.1 pilus assembly protein -
DXN14_RS18765 3769161..3769865 - 705 Protein_3678 integrase core domain-containing protein -
DXN14_RS18770 3769918..3770166 + 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN14_RS18775 3770268..3770576 - 309 WP_010988969.1 hypothetical protein -
DXN14_RS18780 3770659..3770832 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3770860..3771282 - 423 - - Antitoxin
DXN14_RS18785 3771017..3771292 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
DXN14_RS18790 3771345..3771782 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN14_RS18795 3772345..3772791 - 447 WP_000935097.1 protein SciX -
DXN14_RS18800 3772785..3773654 - 870 Protein_3685 polymorphic toxin type 47 domain-containing protein -
DXN14_RS18805 3773718..3773981 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3760008..3773981 13973
flank IS/Tn - - 3769161..3769442 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146373 WP_000994224.1 NZ_CP047525:3771017-3771292 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146373 NZ_CP062744:c2602265-2602158 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 423 bp

>AT146373 NZ_CP047525:c3771282-3770860 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References