221368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 2248123..2248537 Replicon chromosome
Accession NZ_CP085794
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LJF60_RS10595 Protein ID WP_000994230.1
Coordinates 2248123..2248380 (-) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 2248205..2248537 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF60_RS10580 2243734..2244240 + 507 Protein_2041 phage late control D family protein -
LJF60_RS10585 2244240..2247614 + 3375 Protein_2042 RHS domain-containing protein -
LJF60_RS10590 2247611..2248057 + 447 WP_000171102.1 hypothetical protein -
LJF60_RS10595 2248123..2248380 - 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
- 2248205..2248537 + 333 - - Antitoxin
LJF60_RS10600 2248715..2248948 + 234 WP_124084119.1 hypothetical protein -
LJF60_RS10605 2249506..2249823 + 318 WP_001751277.1 hypothetical protein -
LJF60_RS10610 2249820..2250287 + 468 WP_000828182.1 sugar tyrosine-protein kinase -
LJF60_RS10615 2250604..2250882 + 279 WP_012543321.1 hypothetical protein -
LJF60_RS10620 2250949..2251263 - 315 WP_072100769.1 SymE family type I addiction module toxin -
LJF60_RS10625 2251316..2251525 + 210 WP_001676010.1 hypothetical protein -
LJF60_RS10630 2251446..2252016 + 571 Protein_2051 integrase core domain-containing protein -
LJF60_RS10635 2252779..2253276 + 498 WP_016695185.1 Saf-pilin pilus formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2242819..2261910 19091
flank IS/Tn - - 2251738..2252016 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T221368 WP_000994230.1 NZ_CP085794:c2248380-2248123 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T221368 NZ_CP117384:849418-849816 [Salmonella enterica subsp. enterica serovar Uganda]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 333 bp

>AT221368 NZ_CP085794:2248205-2248537 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References