146412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 1244015..1244447 Replicon chromosome
Accession NZ_CP047529
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10640

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag DXN10_RS05815 Protein ID WP_000994224.1
Coordinates 1244015..1244290 (-) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 1244025..1244447 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN10_RS05795 1241326..1241589 + 264 WP_000932531.1 hypothetical protein -
DXN10_RS05800 1241653..1242522 + 870 Protein_1115 polymorphic toxin type 47 domain-containing protein -
DXN10_RS05805 1242516..1242962 + 447 WP_000935097.1 protein SciX -
DXN10_RS05810 1243525..1243962 + 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
DXN10_RS05815 1244015..1244290 - 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
- 1244025..1244447 + 423 - - Antitoxin
DXN10_RS05820 1244532..1244648 + 117 WP_227457392.1 hypothetical protein -
DXN10_RS05825 1244731..1245039 + 309 WP_010988969.1 hypothetical protein -
DXN10_RS05830 1245141..1245389 - 249 WP_001738030.1 SymE family type I addiction module toxin -
DXN10_RS05835 1245442..1246146 + 705 Protein_1122 integrase core domain-containing protein -
DXN10_RS05840 1246896..1247408 + 513 WP_077248260.1 pilus assembly protein -
DXN10_RS05845 1247492..1248229 + 738 WP_001535430.1 pili assembly chaperone SafB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1241749..1256037 14288
flank IS/Tn - - 1245865..1246146 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T146412 WP_000994224.1 NZ_CP047529:c1244290-1244015 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T146412 NZ_CP062746:4464343-4464603 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 423 bp

>AT146412 NZ_CP047529:1244025-1244447 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References