37354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3684436..3684868 Replicon chromosome
Accession NZ_AP023300
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4445

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag K5630_RS18130 Protein ID WP_000994224.1
Coordinates 3684593..3684868 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3684436..3684858 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5630_RS18100 3680654..3681391 - 738 WP_001535430.1 pili assembly chaperone SafB -
K5630_RS18105 3681475..3681987 - 513 WP_077248260.1 pilus assembly protein -
K5630_RS18110 3682737..3683441 - 705 Protein_3562 integrase core domain-containing protein -
K5630_RS18115 3683494..3683742 + 249 WP_001738030.1 SymE family type I addiction module toxin -
K5630_RS18120 3683844..3684152 - 309 WP_010988969.1 hypothetical protein -
K5630_RS18125 3684235..3684408 - 174 WP_088131292.1 RHS repeat-associated core domain-containing protein -
- 3684436..3684858 - 423 - - Antitoxin
K5630_RS18130 3684593..3684868 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
K5630_RS18135 3684921..3685358 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
K5630_RS18140 3685921..3686367 - 447 WP_000935097.1 protein SciX -
K5630_RS18145 3686361..3687230 - 870 Protein_3569 polymorphic toxin type 47 domain-containing protein -
K5630_RS18150 3687294..3687557 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3673584..3687557 13973
flank IS/Tn - - 3682737..3683018 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T37354 WP_000994224.1 NZ_AP023300:3684593-3684868 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

>T37354 NZ_AP023300:3684593-3684868 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 423 bp

>AT37354 NZ_AP023300:c3684858-3684436 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References