Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | IasE-IsrA/SymE(toxin) |
| Location | 3731772..3732204 | Replicon | chromosome |
| Accession | NZ_CP098834 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1 | ||
Toxin (Protein)
| Gene name | IasE | Uniprot ID | E8XIW0 |
| Locus tag | NFH28_RS18600 | Protein ID | WP_000994224.1 |
| Coordinates | 3731929..3732204 (+) | Length | 92 a.a. |
Antitoxin (RNA)
| Gene name | IsrA | ||
| Locus tag | - | ||
| Coordinates | 3731772..3732194 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NFH28_RS18570 | 3727990..3728727 | - | 738 | WP_001535430.1 | pili assembly chaperone SafB | - |
| NFH28_RS18575 | 3728811..3729323 | - | 513 | WP_077248260.1 | pilus assembly protein | - |
| NFH28_RS18580 | 3730073..3730777 | - | 705 | Protein_3642 | integrase core domain-containing protein | - |
| NFH28_RS18585 | 3730830..3731078 | + | 249 | WP_001738030.1 | SymE family type I addiction module toxin | - |
| NFH28_RS18590 | 3731180..3731488 | - | 309 | WP_010988969.1 | hypothetical protein | - |
| NFH28_RS18595 | 3731571..3731744 | - | 174 | WP_088131292.1 | RHS repeat-associated core domain-containing protein | - |
| - | 3731772..3732194 | - | 423 | - | - | Antitoxin |
| NFH28_RS18600 | 3731929..3732204 | + | 276 | WP_000994224.1 | SymE family type I addiction module toxin | Toxin |
| NFH28_RS18605 | 3732257..3732694 | - | 438 | WP_000943619.1 | immunity 26/phosphotriesterase HocA family protein | - |
| NFH28_RS18610 | 3733257..3733703 | - | 447 | WP_000935097.1 | protein SciX | - |
| NFH28_RS18615 | 3733697..3734566 | - | 870 | Protein_3649 | polymorphic toxin type 47 domain-containing protein | - |
| NFH28_RS18620 | 3734630..3734893 | - | 264 | WP_000932531.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 3720920..3734893 | 13973 | ||
| flank | IS/Tn | - | - | 3730073..3730354 | 281 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10032.36 Da Isoelectric Point: 6.4704
>T248158 WP_000994224.1 NZ_CP098834:3731929-3732204 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD
Download Length: 276 bp
Antitoxin
Download Length: 423 bp
>AT248158 NZ_CP098834:c3732194-3731772 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
