263422

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3702299..3702731 Replicon chromosome
Accession NZ_CP110201
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-65

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag OCK73_RS18235 Protein ID WP_000994224.1
Coordinates 3702456..3702731 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3702299..3702721 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCK73_RS18205 3698517..3699254 - 738 WP_001535430.1 pili assembly chaperone SafB -
OCK73_RS18210 3699338..3699850 - 513 WP_077248260.1 pilus assembly protein -
OCK73_RS18215 3700600..3701304 - 705 Protein_3562 integrase core domain-containing protein -
OCK73_RS18220 3701357..3701605 + 249 WP_001738030.1 SymE family type I addiction module toxin -
OCK73_RS18225 3701707..3702015 - 309 WP_010988969.1 hypothetical protein -
OCK73_RS18230 3702098..3702214 - 117 WP_227457392.1 hypothetical protein -
- 3702299..3702721 - 423 - - Antitoxin
OCK73_RS18235 3702456..3702731 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
OCK73_RS18240 3702784..3703221 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
OCK73_RS18245 3703784..3704230 - 447 WP_000935097.1 protein SciX -
OCK73_RS18250 3704224..3705093 - 870 Protein_3569 polymorphic toxin type 47 domain-containing protein -
OCK73_RS18255 3705157..3705420 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3691447..3705420 13973
flank IS/Tn - - 3700600..3700881 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T263422 WP_000994224.1 NZ_CP110201:3702456-3702731 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT263422 NZ_CP110201:c3702721-3702299 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References