Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3736042..3736456 Replicon chromosome
Accession NZ_CP117354
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM099

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag PQP84_RS18600 Protein ID WP_000994230.1
Coordinates 3736199..3736456 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3736042..3736374 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP84_RS18560 3731303..3731755 - 453 WP_001675682.1 Saf-pilin pilus formation protein SafA -
PQP84_RS18565 3732564..3733134 - 571 Protein_3635 integrase core domain-containing protein -
PQP84_RS18570 3733055..3733264 - 210 WP_001676010.1 hypothetical protein -
PQP84_RS18575 3733317..3733631 + 315 WP_072100769.1 SymE family type I addiction module toxin -
PQP84_RS18580 3733698..3733976 - 279 WP_012543321.1 hypothetical protein -
PQP84_RS18585 3734292..3734759 - 468 WP_000828183.1 sugar tyrosine-protein kinase -
PQP84_RS18590 3734756..3735073 - 318 WP_001751277.1 hypothetical protein -
PQP84_RS18595 3735631..3735864 - 234 WP_124084119.1 hypothetical protein -
- 3736042..3736374 - 333 - - Antitoxin
PQP84_RS18600 3736199..3736456 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
PQP84_RS18605 3736522..3736968 - 447 WP_000171102.1 hypothetical protein -
PQP84_RS18610 3736965..3739787 - 2823 Protein_3644 RHS repeat-associated core domain-containing protein -
PQP84_RS18615 3739778..3740044 + 267 WP_223151220.1 SymE family type I addiction module toxin -
PQP84_RS18620 3740162..3740500 - 339 WP_000201550.1 hypothetical protein -
PQP84_RS18625 3740522..3740842 - 321 WP_016695071.1 HNH endonuclease -
PQP84_RS18630 3740900..3741183 - 284 Protein_3648 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3723408..3741736 18328
flank IS/Tn - - 3732564..3732842 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T270750 WP_000994230.1 NZ_CP117354:3736199-3736456 [Salmonella enterica subsp. enterica serovar Dublin]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

Antitoxin


Download         Length: 333 bp

>AT270750 NZ_CP117354:c3736374-3736042 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References