267688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3725323..3725755 Replicon chromosome
Accession NZ_CP116042
Organism Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain BL708

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag PGC28_RS18480 Protein ID WP_000994224.1
Coordinates 3725480..3725755 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3725323..3725745 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGC28_RS18450 3721541..3722278 - 738 WP_001535430.1 pili assembly chaperone SafB -
PGC28_RS18455 3722362..3722874 - 513 WP_077248260.1 pilus assembly protein -
PGC28_RS18460 3723624..3724328 - 705 Protein_3611 integrase core domain-containing protein -
PGC28_RS18465 3724381..3724629 + 249 WP_001738030.1 SymE family type I addiction module toxin -
PGC28_RS18470 3724731..3725039 - 309 WP_010988969.1 hypothetical protein -
PGC28_RS18475 3725122..3725238 - 117 WP_227457392.1 hypothetical protein -
- 3725323..3725745 - 423 - - Antitoxin
PGC28_RS18480 3725480..3725755 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
PGC28_RS18485 3725808..3726245 - 438 WP_283491042.1 immunity 26/phosphotriesterase HocA family protein -
PGC28_RS18490 3726808..3727254 - 447 WP_000935097.1 protein SciX -
PGC28_RS18495 3727248..3728117 - 870 Protein_3618 polymorphic toxin type 47 domain-containing protein -
PGC28_RS18500 3728181..3728444 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3714471..3728444 13973
flank IS/Tn - - 3723624..3723905 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T267688 WP_000994224.1 NZ_CP116042:3725480-3725755 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT267688 NZ_CP116042:c3725745-3725323 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References