218838

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3601727..3602141 Replicon chromosome
Accession NZ_CP084532
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE211

Toxin (Protein)


Gene name IasE Uniprot ID M7RBD3
Locus tag LDP70_RS17705 Protein ID WP_000994230.1
Coordinates 3601884..3602141 (+) Length 86 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3601727..3602059 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDP70_RS17665 3596988..3597485 - 498 WP_016695185.1 Saf-pilin pilus formation protein -
LDP70_RS17670 3598248..3598818 - 571 Protein_3460 integrase core domain-containing protein -
LDP70_RS17675 3598739..3598948 - 210 WP_001676010.1 hypothetical protein -
LDP70_RS17680 3599001..3599315 + 315 WP_072100769.1 SymE family type I addiction module toxin -
LDP70_RS17685 3599382..3599660 - 279 WP_012543321.1 hypothetical protein -
LDP70_RS17690 3599977..3600444 - 468 WP_000828182.1 sugar tyrosine-protein kinase -
LDP70_RS17695 3600441..3600758 - 318 WP_001751277.1 hypothetical protein -
LDP70_RS17700 3601316..3601549 - 234 WP_124084119.1 hypothetical protein -
- 3601727..3602059 - 333 - - Antitoxin
LDP70_RS17705 3601884..3602141 + 258 WP_000994230.1 SymE family type I addiction module toxin Toxin
LDP70_RS17710 3602207..3602653 - 447 WP_000171102.1 hypothetical protein -
LDP70_RS17715 3602650..3606024 - 3375 Protein_3469 RHS domain-containing protein -
LDP70_RS17720 3606024..3606530 - 507 Protein_3470 phage late control D family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3591419..3605946 14527
flank IS/Tn - - 3598248..3598526 278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-56)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9490.94 Da        Isoelectric Point: 9.5519

>T218838 WP_000994230.1 NZ_CP084532:3601884-3602141 [Salmonella enterica subsp. enterica serovar Enteritidis]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Download         Length: 258 bp

>T218838 NZ_CP116108:c95911-95762 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 333 bp

>AT218838 NZ_CP084532:c3602059-3601727 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IER2

Antitoxin

Download structure file

References