Detailed information of TA system TA201412

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 339391..339823
• Replicon: chromosome
• Accession: NZ_CP074096
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain 2B_cip

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: KFV00_RS01495
• Protein ID: WP_000994224.1
• Coordinates: 339391..339666 (-)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	339401..339823 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFV00_RS01475	336702..336965	+	264	WP_000932531.1	hypothetical protein	-
KFV00_RS01480	337029..337898	+	870	Protein_288	polymorphic toxin type 47 domain-containing protein	-
KFV00_RS01485	337892..338338	+	447	WP_000935097.1	protein SciX	-
KFV00_RS01490	338901..339338	+	438	WP_000943619.1	immunity 26/phosphotriesterase HocA family protein	-
KFV00_RS01495	339391..339666	-	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
-	339401..339823	+	423	-	-	Antitoxin
KFV00_RS24030	339851..340024	+	174	WP_088131292.1	RHS repeat-associated core domain-containing protein	-
KFV00_RS01505	340107..340385	+	279	WP_012664366.1	hypothetical protein	-
KFV00_RS01510	340517..340765	-	249	Protein_294	SymE family type I addiction module toxin	-
KFV00_RS01515	340818..341522	+	705	Protein_295	integrase core domain-containing protein	-
KFV00_RS01520	342272..342784	+	513	WP_010988970.1	Saf-pilin pilus formation protein SafA	-
KFV00_RS01525	342868..343605	+	738	WP_212634398.1	pili assembly chaperone SafB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016810 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 Genomic island TA010103 336540..350828 0.006 View NC_016856 Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S Genomic island TA026042 337747..352035 0.006	inside	Genomic island	-	-	337125..351413	14288
	-	flank	IS/Tn	-	-	341241..341522	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T201412 WP_000994224.1 NZ_CP074096:c339666-339391 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

>T201412 NZ_CP098354:83017-83415 [Klebsiella pneumoniae]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin

Nucleotide

• Length: 423 bp

>AT201412 NZ_CP074096:339401-339823 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin