Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) IasE-IsrA/SymE(toxin)
Location 3682368..3682800 Replicon chromosome
Accession NZ_CP100715
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.5474

Toxin (Protein)


Gene name IasE Uniprot ID E8XIW0
Locus tag NL730_RS18250 Protein ID WP_000994224.1
Coordinates 3682525..3682800 (+) Length 92 a.a.

Antitoxin (RNA)


Gene name IsrA
Locus tag -
Coordinates 3682368..3682790 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL730_RS18220 3678069..3678581 - 513 WP_077248260.1 pilus assembly protein -
NL730_RS18225 3679300..3680508 + 1209 WP_006250222.1 IS4-like element ISVsa5 family transposase -
NL730_RS18230 3680669..3681373 - 705 Protein_3566 integrase core domain-containing protein -
NL730_RS18235 3681426..3681674 + 249 WP_001738030.1 SymE family type I addiction module toxin -
NL730_RS18240 3681776..3682084 - 309 WP_010988969.1 hypothetical protein -
NL730_RS18245 3682167..3682283 - 117 WP_227457392.1 hypothetical protein -
- 3682368..3682790 - 423 - - Antitoxin
NL730_RS18250 3682525..3682800 + 276 WP_000994224.1 SymE family type I addiction module toxin Toxin
NL730_RS18255 3682853..3683290 - 438 WP_000943619.1 immunity 26/phosphotriesterase HocA family protein -
NL730_RS18260 3683853..3684299 - 447 WP_000935097.1 protein SciX -
NL730_RS18265 3684293..3685162 - 870 Protein_3573 polymorphic toxin type 47 domain-containing protein -
NL730_RS18270 3685226..3685489 - 264 WP_000932531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3670178..3685489 15311
inside Genomic island - - 3672502..3685489 12987


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(14-57)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10032.36 Da        Isoelectric Point: 6.4704

>T251185 WP_000994224.1 NZ_CP100715:3682525-3682800 [Salmonella enterica subsp. enterica serovar Typhimurium]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Download         Length: 276 bp

Antitoxin


Download         Length: 423 bp

>AT251185 NZ_CP100715:c3682790-3682368 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JPW5

Antitoxin

Download structure file

References