Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1533875..1534401 Replicon chromosome
Accession NZ_HG738867
Organism Escherichia coli str. K-12 substr. MC4100 strain K-12

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag BN896_RS07645 Protein ID WP_000323025.1
Coordinates 1533875..1534162 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag BN896_RS07650 Protein ID WP_000534858.1
Coordinates 1534162..1534401 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN896_RS07605 (BN896_1375) 1528899..1529114 - 216 WP_000839590.1 phage lysis protein EssD -
BN896_RS07610 (BN896_1376) 1529868..1530083 - 216 WP_000066484.1 cold shock-like protein CspB -
BN896_RS07615 (BN896_1377) 1530384..1530596 + 213 WP_000087756.1 cold shock-like protein CspF -
BN896_RS25110 1530651..1530740 + 90 WP_120795389.1 hypothetical protein -
BN896_RS07620 (BN896_1378) 1531018..1531770 - 753 WP_001047135.1 antitermination protein -
BN896_RS07625 (BN896_1379) 1531784..1532833 - 1050 WP_001265198.1 DUF968 domain-containing protein -
BN896_RS07630 1532835..1533113 - 279 WP_012304870.1 hypothetical protein -
BN896_RS07635 (BN896_1380) 1533180..1533431 - 252 WP_000980994.1 hypothetical protein -
BN896_RS07640 (BN896_1381) 1533648..1533803 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
BN896_RS07645 (BN896_1382) 1533875..1534162 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
BN896_RS07650 (BN896_1383) 1534162..1534401 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
BN896_RS23255 (BN896_1384) 1534426..1534731 + 306 WP_001326990.1 hypothetical protein -
BN896_RS07655 (BN896_1385) 1534934..1535266 + 333 WP_001301033.1 protein FlxA -
BN896_RS22595 (BN896_1386) 1535703..1535852 - 150 WP_011443592.1 hypothetical protein -
BN896_RS07660 (BN896_1387) 1535887..1536165 - 279 Protein_1460 hypothetical protein -
BN896_RS07665 (BN896_1388) 1536149..1536379 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
BN896_RS07670 (BN896_1389) 1536463..1536870 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
BN896_RS07675 (BN896_1390) 1537037..1537192 + 156 WP_000379575.1 DUF1391 family protein -
BN896_RS07680 1537352..1537570 + 219 WP_001171942.1 hypothetical protein -
BN896_RS07690 (BN896_1392) 1538138..1538326 + 189 WP_000854559.1 cell division inhibition protein DicB -
BN896_RS07695 (BN896_1393) 1538323..1538514 + 192 WP_001083297.1 lysis protein YdfD -
BN896_RS23270 1538607..1539374 + 768 Protein_1467 exonuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1519531..1552992 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T285017 WP_000323025.1 NZ_HG738867:c1534162-1533875 [Escherichia coli str. K-12 substr. MC4100]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T285017 NZ_HG738867:c1534162-1533875 [Escherichia coli str. K-12 substr. MC4100]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT285017 WP_000534858.1 NZ_HG738867:c1534401-1534162 [Escherichia coli str. K-12 substr. MC4100]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT285017 NZ_HG738867:c1534401-1534162 [Escherichia coli str. K-12 substr. MC4100]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References