196524

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2239618..2240144 Replicon chromosome
Accession NZ_CP071521
Organism Escherichia coli strain 11202

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag J2D70_RS10825 Protein ID WP_000323025.1
Coordinates 2239857..2240144 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag J2D70_RS10820 Protein ID WP_000534858.1
Coordinates 2239618..2239857 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J2D70_RS10765 (2234645) 2234645..2235412 - 768 Protein_2114 exonuclease -
J2D70_RS10770 (2235505) 2235505..2235696 - 192 WP_001083297.1 lysis protein YdfD -
J2D70_RS10775 (2235693) 2235693..2235881 - 189 WP_000854559.1 cell division inhibition protein DicB -
J2D70_RS10780 (2236449) 2236449..2236667 - 219 WP_001171942.1 protein YdfC -
J2D70_RS23000 (2236697) 2236697..2236825 - 129 WP_000344964.1 protein YdfB -
J2D70_RS10785 (2236827) 2236827..2236982 - 156 WP_000379575.1 DUF1391 family protein -
J2D70_RS10790 (2237149) 2237149..2237556 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
J2D70_RS10795 (2237640) 2237640..2237870 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
J2D70_RS10800 (2237854) 2237854..2238132 + 279 Protein_2122 protein YdfX -
J2D70_RS10805 (2238167) 2238167..2238316 + 150 WP_011443592.1 protein YdfW -
J2D70_RS10810 (2238753) 2238753..2239085 - 333 WP_001301033.1 FlxA-like family protein -
J2D70_RS10815 (2239288) 2239288..2239593 - 306 WP_001326990.1 protein YdfV -
J2D70_RS10820 (2239618) 2239618..2239857 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
J2D70_RS10825 (2239857) 2239857..2240144 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
J2D70_RS10830 (2240216) 2240216..2240371 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
J2D70_RS10835 (2240588) 2240588..2240839 + 252 WP_000980994.1 protein Rem -
J2D70_RS10840 (2240906) 2240906..2241184 + 279 WP_012304870.1 hypothetical protein -
J2D70_RS10845 (2241186) 2241186..2242235 + 1050 WP_001265198.1 DUF968 domain-containing protein -
J2D70_RS10850 (2242249) 2242249..2243001 + 753 WP_001047135.1 antitermination protein -
J2D70_RS10855 (2243279) 2243279..2243368 - 90 WP_120795389.1 hypothetical protein -
J2D70_RS10860 (2243423) 2243423..2243635 - 213 WP_000087756.1 cold shock-like protein CspF -
J2D70_RS10865 (2243936) 2243936..2244151 + 216 WP_000066484.1 cold shock-like protein CspB -
J2D70_RS10870 (2244515) 2244515..2244685 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
J2D70_RS10875 (2244905) 2244905..2245120 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2215898..2254488 38590


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T196524 WP_000323025.1 NZ_CP071521:2239857-2240144 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T196524 NZ_CP095150:c4865719-4865435 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT196524 WP_000534858.1 NZ_CP071521:2239618-2239857 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT196524 NZ_CP095150:c4865951-4865709 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References