Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2240997..2241523 Replicon chromosome
Accession NZ_CP042867
Organism Escherichia coli strain ATCC BAA-196

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag BAA196FS_RS10870 Protein ID WP_000323025.1
Coordinates 2241236..2241523 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag BAA196FS_RS10865 Protein ID WP_000534858.1
Coordinates 2240997..2241236 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA196FS_RS10805 2236024..2236791 - 768 Protein_2096 exonuclease -
BAA196FS_RS10810 2236884..2237075 - 192 WP_001083297.1 lysis protein YdfD -
BAA196FS_RS10815 2237072..2237260 - 189 WP_000854559.1 cell division inhibition protein DicB -
BAA196FS_RS10820 2237660..2237824 + 165 WP_014639039.1 hypothetical protein -
BAA196FS_RS10825 2237828..2238046 - 219 WP_001171942.1 hypothetical protein -
BAA196FS_RS10830 2238206..2238361 - 156 WP_000379575.1 DUF1391 family protein -
BAA196FS_RS10835 2238528..2238935 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
BAA196FS_RS10840 2239019..2239249 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
BAA196FS_RS10845 2239233..2239511 + 279 Protein_2104 hypothetical protein -
BAA196FS_RS10850 2239546..2239695 + 150 WP_011443592.1 hypothetical protein -
BAA196FS_RS10855 2240132..2240464 - 333 WP_001301033.1 protein FlxA -
BAA196FS_RS10860 2240667..2240972 - 306 WP_001326990.1 hypothetical protein -
BAA196FS_RS10865 2240997..2241236 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
BAA196FS_RS10870 2241236..2241523 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
BAA196FS_RS10875 2241595..2241750 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
BAA196FS_RS10880 2241967..2242218 + 252 WP_000980994.1 hypothetical protein -
BAA196FS_RS10885 2242285..2242563 + 279 WP_012304870.1 hypothetical protein -
BAA196FS_RS10890 2242565..2243614 + 1050 WP_001265198.1 DUF968 domain-containing protein -
BAA196FS_RS10895 2243628..2244380 + 753 WP_001047135.1 antitermination protein -
BAA196FS_RS10900 2244658..2244747 - 90 WP_120795389.1 hypothetical protein -
BAA196FS_RS10905 2244802..2245014 - 213 WP_000087756.1 cold shock-like protein CspF -
BAA196FS_RS10910 2245315..2245530 + 216 WP_000066484.1 cold shock-like protein CspB -
BAA196FS_RS10915 2246284..2246499 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2228999..2255867 26868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T136338 WP_000323025.1 NZ_CP042867:2241236-2241523 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T136338 NZ_CP055599:224730-224833 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT136338 WP_000534858.1 NZ_CP042867:2240997-2241236 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT136338 NZ_CP042867:2240997-2241236 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References