136338

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2240997..2241523 Replicon chromosome
Accession NZ_CP042867
Organism Escherichia coli strain ATCC BAA-196

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag BAA196FS_RS10870 Protein ID WP_000323025.1
Coordinates 2241236..2241523 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag BAA196FS_RS10865 Protein ID WP_000534858.1
Coordinates 2240997..2241236 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA196FS_RS10805 2236024..2236791 - 768 Protein_2096 exonuclease -
BAA196FS_RS10810 2236884..2237075 - 192 WP_001083297.1 lysis protein YdfD -
BAA196FS_RS10815 2237072..2237260 - 189 WP_000854559.1 cell division inhibition protein DicB -
BAA196FS_RS10820 2237660..2237824 + 165 WP_014639039.1 hypothetical protein -
BAA196FS_RS10825 2237828..2238046 - 219 WP_001171942.1 hypothetical protein -
BAA196FS_RS10830 2238206..2238361 - 156 WP_000379575.1 DUF1391 family protein -
BAA196FS_RS10835 2238528..2238935 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
BAA196FS_RS10840 2239019..2239249 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
BAA196FS_RS10845 2239233..2239511 + 279 Protein_2104 hypothetical protein -
BAA196FS_RS10850 2239546..2239695 + 150 WP_011443592.1 hypothetical protein -
BAA196FS_RS10855 2240132..2240464 - 333 WP_001301033.1 protein FlxA -
BAA196FS_RS10860 2240667..2240972 - 306 WP_001326990.1 hypothetical protein -
BAA196FS_RS10865 2240997..2241236 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
BAA196FS_RS10870 2241236..2241523 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
BAA196FS_RS10875 2241595..2241750 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
BAA196FS_RS10880 2241967..2242218 + 252 WP_000980994.1 hypothetical protein -
BAA196FS_RS10885 2242285..2242563 + 279 WP_012304870.1 hypothetical protein -
BAA196FS_RS10890 2242565..2243614 + 1050 WP_001265198.1 DUF968 domain-containing protein -
BAA196FS_RS10895 2243628..2244380 + 753 WP_001047135.1 antitermination protein -
BAA196FS_RS10900 2244658..2244747 - 90 WP_120795389.1 hypothetical protein -
BAA196FS_RS10905 2244802..2245014 - 213 WP_000087756.1 cold shock-like protein CspF -
BAA196FS_RS10910 2245315..2245530 + 216 WP_000066484.1 cold shock-like protein CspB -
BAA196FS_RS10915 2246284..2246499 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2228999..2255867 26868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T136338 WP_000323025.1 NZ_CP042867:2241236-2241523 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T136338 NZ_CP055599:224730-224833 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT136338 WP_000534858.1 NZ_CP042867:2240997-2241236 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT136338 NZ_CP042867:2240997-2241236 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References