Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 2240997..2241523 | Replicon | chromosome |
Accession | NZ_CP042867 | ||
Organism | Escherichia coli strain ATCC BAA-196 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | BAA196FS_RS10870 | Protein ID | WP_000323025.1 |
Coordinates | 2241236..2241523 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | BAA196FS_RS10865 | Protein ID | WP_000534858.1 |
Coordinates | 2240997..2241236 (+) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BAA196FS_RS10805 | 2236024..2236791 | - | 768 | Protein_2096 | exonuclease | - |
BAA196FS_RS10810 | 2236884..2237075 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
BAA196FS_RS10815 | 2237072..2237260 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
BAA196FS_RS10820 | 2237660..2237824 | + | 165 | WP_014639039.1 | hypothetical protein | - |
BAA196FS_RS10825 | 2237828..2238046 | - | 219 | WP_001171942.1 | hypothetical protein | - |
BAA196FS_RS10830 | 2238206..2238361 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
BAA196FS_RS10835 | 2238528..2238935 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
BAA196FS_RS10840 | 2239019..2239249 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
BAA196FS_RS10845 | 2239233..2239511 | + | 279 | Protein_2104 | hypothetical protein | - |
BAA196FS_RS10850 | 2239546..2239695 | + | 150 | WP_011443592.1 | hypothetical protein | - |
BAA196FS_RS10855 | 2240132..2240464 | - | 333 | WP_001301033.1 | protein FlxA | - |
BAA196FS_RS10860 | 2240667..2240972 | - | 306 | WP_001326990.1 | hypothetical protein | - |
BAA196FS_RS10865 | 2240997..2241236 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
BAA196FS_RS10870 | 2241236..2241523 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
BAA196FS_RS10875 | 2241595..2241750 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
BAA196FS_RS10880 | 2241967..2242218 | + | 252 | WP_000980994.1 | hypothetical protein | - |
BAA196FS_RS10885 | 2242285..2242563 | + | 279 | WP_012304870.1 | hypothetical protein | - |
BAA196FS_RS10890 | 2242565..2243614 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
BAA196FS_RS10895 | 2243628..2244380 | + | 753 | WP_001047135.1 | antitermination protein | - |
BAA196FS_RS10900 | 2244658..2244747 | - | 90 | WP_120795389.1 | hypothetical protein | - |
BAA196FS_RS10905 | 2244802..2245014 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
BAA196FS_RS10910 | 2245315..2245530 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
BAA196FS_RS10915 | 2246284..2246499 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2228999..2255867 | 26868 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T136338 WP_000323025.1 NZ_CP042867:2241236-2241523 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T136338 NZ_CP055599:224730-224833 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT136338 WP_000534858.1 NZ_CP042867:2240997-2241236 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT136338 NZ_CP042867:2240997-2241236 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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