Detailed information of TA system TA027404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1627528..1628054
• Replicon: chromosome
• Accession: NC_017638
• Organism: Escherichia coli DH1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1EXL1
• Locus tag: ECDH1ME8569_RS08045
• Protein ID: WP_000323025.1
• Coordinates: 1627528..1627815 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S1F6D3
• Locus tag: ECDH1ME8569_RS08050
• Protein ID: WP_000534858.1
• Coordinates: 1627815..1628054 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECDH1ME8569_RS08005 (ECDH1ME8569_1500)	1622552..1622767	-	216	WP_000839590.1	phage lysis protein EssD	-
ECDH1ME8569_RS08010 (ECDH1ME8569_1501)	1623521..1623736	-	216	WP_000066484.1	cold shock-like protein CspB	-
ECDH1ME8569_RS08015 (ECDH1ME8569_1502)	1624037..1624249	+	213	WP_000087756.1	cold shock-like protein CspF	-
ECDH1ME8569_RS24910	1624304..1624393	+	90	WP_120795389.1	hypothetical protein	-
ECDH1ME8569_RS08020 (ECDH1ME8569_1503)	1624671..1625423	-	753	WP_001047135.1	antitermination protein	-
ECDH1ME8569_RS08025 (ECDH1ME8569_1504)	1625437..1626486	-	1050	WP_001265198.1	DUF968 domain-containing protein	-
ECDH1ME8569_RS08030	1626488..1626766	-	279	WP_012304870.1	hypothetical protein	-
ECDH1ME8569_RS08035 (ECDH1ME8569_1505)	1626833..1627084	-	252	WP_000980994.1	hypothetical protein	-
ECDH1ME8569_RS08040 (ECDH1ME8569_1506)	1627301..1627456	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	-
ECDH1ME8569_RS08045 (ECDH1ME8569_1507)	1627528..1627815	-	288	WP_000323025.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
ECDH1ME8569_RS08050 (ECDH1ME8569_1508)	1627815..1628054	-	240	WP_000534858.1	type II toxin-antitoxin system antitoxin RelB	Antitoxin
ECDH1ME8569_RS23705 (ECDH1ME8569_1509)	1628079..1628384	+	306	WP_001326990.1	hypothetical protein	-
ECDH1ME8569_RS08055 (ECDH1ME8569_1510)	1628587..1628919	+	333	WP_001301033.1	protein FlxA	-
ECDH1ME8569_RS22990 (ECDH1ME8569_1511)	1629356..1629505	-	150	WP_011443592.1	hypothetical protein	-
ECDH1ME8569_RS08060 (ECDH1ME8569_1512)	1629540..1629818	-	279	Protein_1548	hypothetical protein	-
ECDH1ME8569_RS08065 (ECDH1ME8569_1513)	1629802..1630032	-	231	WP_000920568.1	dicB transcriptional regulator DicC	-
ECDH1ME8569_RS08070 (ECDH1ME8569_1514)	1630116..1630523	+	408	WP_000448564.1	DNA-binding transcriptional dual regulator DicA	-
ECDH1ME8569_RS08075 (ECDH1ME8569_1515)	1630690..1630845	+	156	WP_000379575.1	DUF1391 family protein	-
ECDH1ME8569_RS08080 (ECDH1ME8569_1517)	1631005..1631223	+	219	WP_001171942.1	hypothetical protein	-
ECDH1ME8569_RS08090 (ECDH1ME8569_1518)	1631791..1631979	+	189	WP_000854559.1	cell division inhibition protein DicB	-
ECDH1ME8569_RS08095 (ECDH1ME8569_1519)	1631976..1632167	+	192	WP_001083297.1	lysis protein YdfD	-
ECDH1ME8569_RS23715 (ECDH1ME8569_1520)	1632260..1633027	+	768	Protein_1555	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View CP009789 Escherichia coli K-12 strain ER3413 Prophage TA020026 1611431..1634475 0.004 View NC_007779 Escherichia coli str. K-12 substr. W3110 Prophage TA021438 1632716..1654422 0.003 View NC_007779 Escherichia coli str. K-12 substr. W3110 Prophage TA021438 1632716..1654422 0.003 View CP009789 Escherichia coli K-12 strain ER3413 Prophage TA020026 1611431..1634475 0.004 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Prophage TA068425 1534772..1559021 0.005 View NZ_CP025520 Escherichia coli strain DH5alpha Prophage TA090479 488442..510148 0.003 View NC_017625 Escherichia coli DH1 Prophage TA027170 2221734..2249263 0.009 View NZ_CP008801 Escherichia coli KLY Prophage TA047503 1603634..1629197 0.007 View NZ_CP009644 Escherichia coli ER2796 strain K-12 ER2796 Prophage TA049364 1611430..1634474 0.004 View NZ_CP009789 Escherichia coli K-12 strain K-12 ER3413 Prophage TA049791 1611431..1634475 0.004 View NZ_CP010438 Escherichia coli K-12 strain K-12 MG1655 Prophage TA052436 2386667..2409580 0.005 View NZ_CP010439 Escherichia coli K-12 strain K-12 MG1655 Prophage TA052469 2371482..2397224 0.008 View NZ_CP010440 Escherichia coli K-12 strain K-12 MG1655 Prophage TA052507 2388114..2409820 0.003 View NZ_CP010442 Escherichia coli K-12 strain K-12 MG1655 Prophage TA052590 2427371..2449077 0.003 View NZ_CP010444 Escherichia coli K-12 strain K-12 MG1655 Prophage TA052672 2376569..2399482 0.005 View NZ_CP010445 Escherichia coli K-12 strain K-12 MG1655 Prophage TA052714 2427370..2449076 0.003 View NZ_CP011113 Escherichia coli strain RR1 Prophage TA053405 1593305..1621509 0.009 View NZ_CP011320 Escherichia coli strain SQ37 Prophage TA053844 1629027..1650733 0.003 View NZ_CP011321 Escherichia coli strain SQ88 Prophage TA053887 1626109..1645195 0 View NZ_CP011322 Escherichia coli strain SQ110 Prophage TA053930 1626108..1645194 0 View NZ_CP011324 Escherichia coli strain SQ2203 Prophage TA053973 1626109..1645195 0 View NZ_CP011342 Escherichia coli K-12 substr. GM4792 Prophage TA054060 1612692..1634398 0.003 View NZ_CP011495 Escherichia coli strain NCM3722 isolate K-12 Prophage TA054325 2885760..2906182 0 View NZ_CP012125 Escherichia coli strain DH1Ec095 Prophage TA055840 1615805..1634891 0 View NZ_CP012126 Escherichia coli strain DH1Ec104 Prophage TA055883 1615806..1634892 0 View NZ_CP013952 Escherichia coli strain HST04 Prophage TA059671 4226718..4253586 0.009 View NZ_CP014270 Escherichia coli K-12 strain K-12 DHB4 Prophage TA060527 1536107..1559149 0.003 View NZ_CP014272 Escherichia coli K-12 strain K-12 C3026 Prophage TA060579 1735171..1759420 0.005 View NZ_CP016018 Escherichia coli strain ER1821R Prophage TA064139 2227145..2248851 0.003 View NZ_CP017100 Escherichia coli strain K-12 NEB 5-alpha Prophage TA065978 1576886..1599799 0.004 View NZ_CP026026 Escherichia coli strain CAR Prophage TA092762 1629026..1650732 0.003 View NZ_CP026027 Escherichia coli strain LIM Prophage TA092803 1629027..1650733 0.003 View NZ_CP026028 Escherichia coli strain CIT Prophage TA092846 1629027..1650733 0.003 View NZ_CP026342 Escherichia coli strain 9FA Prophage TA093861 1631002..1657870 0.009 View NZ_CP026346 Escherichia coli strain 7FA Prophage TA094033 1631002..1657870 0.009 View NZ_CP026351 Escherichia coli strain 5A Prophage TA094248 1631002..1657870 0.009 View NZ_CP026352 Escherichia coli strain 4FA Prophage TA094291 1631002..1657870 0.009 View NZ_CP026354 Escherichia coli strain 3FA Prophage TA094377 1629215..1656744 0.009 View NZ_CP026358 Escherichia coli strain 2A Prophage TA094549 1631002..1657870 0.009 View NZ_CP026612 Escherichia coli strain DTU-1 Prophage TA095275 3159040..3179401 0.004 View NZ_CP028702 Escherichia coli strain J53 Prophage TA102958 2064330..2086036 0.003 View NZ_CP028703 Escherichia coli strain ME8067 Prophage TA103002 2489209..2510915 0.003 View NZ_CP029239 Escherichia coli strain BH212 Prophage TA105287 1676357..1699399 0.003 View NZ_CP040664 Escherichia coli strain KR2009 Prophage TA126395 1618743..1640164 0.003 View NZ_CP042865 Escherichia coli strain ATCC BAA-196 Prophage TA136307 2229091..2255959 0.009 View NZ_CP042867 Escherichia coli strain ATCC BAA-196 Prophage TA136338 2228999..2255867 0.009 View NZ_CP043185 Escherichia coli O16:H48 strain PG20180171 Prophage TA137428 360597..386339 0.008 View NZ_CP043193 Escherichia coli O16:H48 strain PG20180063 Prophage TA137571 2226806..2253674 0.009 View NZ_CP043199 Escherichia coli O16:H48 strain PG20180060 Prophage TA137672 2664248..2685954 0.003 View NZ_CP043205 Escherichia coli O16:H48 strain PG20180054 Prophage TA137777 2227930..2253672 0.008 View NZ_CP043211 Escherichia coli O16:H48 strain PG20180050 Prophage TA137876 2516941..2538647 0.003 View NZ_CP043213 Escherichia coli O16:H48 strain CV601gfp Prophage TA137913 2102857..2124563 0.003 View NZ_CP046025 Escherichia coli strain C439 Prophage TA143414 2233302..2255008 0.003 View NZ_CP053603 Escherichia coli strain Dam/Dcm Prophage TA157065 1615047..1641915 0.009 View NZ_CP053604 Escherichia coli strain NEB10-beta Prophage TA157102 1721269..1744311 0.003 View NZ_CP053605 Escherichia coli strain NEB_Turbo Prophage TA157132 1517365..1540270 0.004 View NZ_CP053607 Escherichia coli strain NEB5-alpha_F'Iq Prophage TA157177 1577899..1599604 0.003 View NZ_CP054665 Escherichia coli strain IGC_EcoliInv_1.1 Prophage TA160046 1635819..1661561 0.008 View NZ_CP058948 Escherichia coli strain SY3626C5 Prophage TA168003 2064038..2085744 0.003 View NZ_CP059043 Escherichia coli strain SY3626C1 Prophage TA168131 2064038..2085744 0.003 View NZ_CP062242 Escherichia coli strain AML001_par Prophage TA173775 1625259..1652127 0.009 View NZ_CP062247 Escherichia coli strain AML002_ev03 Prophage TA173990 1626462..1649375 0.004 View NZ_CP062248 Escherichia coli strain AML002_ev02 Prophage TA174033 1625260..1652128 0.009 View NZ_CP062249 Escherichia coli strain AML002_ev01 Prophage TA174076 1626458..1649371 0.004 View NZ_CP064679 Escherichia coli K-12 strain CETR2G40 Prophage TA181470 1625259..1652127 0.009 View NZ_CP064681 Escherichia coli K-12 strain BZKR3G40 Prophage TA181556 1625259..1652127 0.009 View NZ_CP070482 Escherichia coli strain BTH101 Prophage TA194142 1077771..1100813 0.003 View NZ_CP070962 Escherichia coli strain K-12 J53 Prophage TA194816 1907593..1935799 0.01 View NZ_CP072986 Escherichia coli strain T159A Prophage TA199413 2233302..2255008 0.003 View NZ_CP076404 Escherichia coli strain K-12 substr. AB1157 Prophage TA205629 1588934..1610640 0.003 View NZ_CP079735 Escherichia coli strain GB2005 Prophage TA209827 2227908..2250948 0.003 View NZ_CP083610 Escherichia coli strain EC2648-Vir1 Prophage TA216849 3708214..3729920 0.003 View NZ_CP083990 Escherichia coli strain EC2648-Vir2 Prophage TA217894 2226787..2250280 0.005 View NZ_CP084205 Escherichia coli strain EC2648-R1 Prophage TA218214 2226752..2251108 0.006 View NZ_CP084207 Escherichia coli strain EC2648-R1-1 Prophage TA218255 3031857..3059386 0.009 View NZ_CP084209 Escherichia coli strain EC2648-R2 Prophage TA218286 2222730..2250021 0.009 View NZ_CP084893 Escherichia coli strain g94 Prophage TA219827 1634347..1656053 0.003 View NZ_CP084895 Escherichia coli strain g74 Prophage TA219913 1634347..1656053 0.003 View NZ_CP084897 Escherichia coli strain gb37 Prophage TA219999 1634347..1660089 0.008 View NZ_CP084899 Escherichia coli strain W3110-P Prophage TA220085 1634347..1656053 0.003 View NZ_CP087136 Escherichia coli strain JW5503 Prophage TA224831 1625806..1652674 0.009 View NZ_CP091065 Escherichia coli strain DOC14 Prophage TA232627 2048147..2069853 0.003 View NZ_CP092702 Escherichia coli strain S-P-C-029.01 Prophage TA236980 1631002..1657870 0.009 View NZ_CP093221 Escherichia coli strain ER2683 Prophage TA237841 3343923..3370791 0.009 View NZ_CP093368 Escherichia coli strain EV36 mutant 1a Prophage TA238251 2485630..2512498 0.009 View NZ_CP099588 Escherichia coli strain EMG2 Prophage TA249145 2216211..2239704 0.005 View NZ_CP104328 Escherichia coli strain THB42-F2 Prophage TA257630 2227055..2248761 0.003 View NZ_CP104330 Escherichia coli strain THB42-F3 Prophage TA257660 2226752..2250245 0.005 View NZ_CP110814 Escherichia coli strain THB42-F4 Prophage TA264306 2226863..2248569 0.003 View NZ_CP110816 Escherichia coli strain THB42-F5 Prophage TA264338 2226752..2250245 0.005 View NZ_CP110816 Escherichia coli strain THB42-F5 Prophage TA264338 2226752..2251108 0.006 View NZ_CP110859 Escherichia coli strain TSW4881-W1 Prophage TA264399 2237424..2260466 0.004 View NZ_CP114894 Escherichia coli strain CM19 Prophage TA266969 982542..1005584 0.003 View NZ_CP114895 Escherichia coli strain CM56 Prophage TA267002 2271311..2294353 0.003 View NZ_CP114896 Escherichia coli strain CM93 Prophage TA267021 1086542..1109584 0.003 View NZ_CP117962 Escherichia coli strain JM109 Prophage TA272541 6709..30202 0.005 View NZ_CP122315 Escherichia coli strain HT-947 Prophage TA276647 3042452..3064158 0.003 View NZ_CP122317 Escherichia coli strain HT-948 Prophage TA276688 162513..184219 0.003 View NZ_CP122319 Escherichia coli strain BW25113 Prophage TA276777 4066853..4089766 0.004 View NZ_LM993812 Escherichia coli strain K-12 substr. HMS174 Prophage TA285399 1600962..1621216 0.007 View NZ_LT615378 Escherichia coli isolate 103 Prophage TA293374 1634656..1661524 0.009 View NZ_CP017979 Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 Prophage TA068425 1534772..1559021 0.005 View NZ_CP025520 Escherichia coli strain DH5alpha Prophage TA090479 488442..510148 0.003	inside	Prophage	-	-	1615804..1634890	19086

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-79)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11225.22 Da
• Isoelectric Point: 10.1967

>T27404 WP_000323025.1 NC_017638:c1627815-1627528 [Escherichia coli DH1]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Nucleotide

• Length: 288 bp

>T27404 NC_017638:c1627815-1627528 [Escherichia coli DH1]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9071.48 Da
• Isoelectric Point: 4.5230

>AT27404 WP_000534858.1 NC_017638:c1628054-1627815 [Escherichia coli DH1]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Nucleotide

• Length: 240 bp

>AT27404 NC_017638:c1628054-1627815 [Escherichia coli DH1]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• PDB: 4V7K
• PDB: 4V7J
• PDB: 4FXI
• PDB: 4FXE
• PDB: 2KC8
• PDB: 4FXH
• PDB: 2KC9

Antitoxin

• PDB: 4FXE
• PDB: 2KC8
• PDB: 2K29
• AlphaFold DB: A0A4V1CTS8