266969

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 996886..997412 Replicon chromosome
Accession NZ_CP114894
Organism Escherichia coli strain CM19

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag O6X69_RS04980 Protein ID WP_000323025.1
Coordinates 996886..997173 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag O6X69_RS04985 Protein ID WP_000534858.1
Coordinates 997173..997412 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6X69_RS04930 (991910) 991910..992125 - 216 WP_000839590.1 phage lysis protein EssD -
O6X69_RS04935 (992345) 992345..992515 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
O6X69_RS04940 (992879) 992879..993094 - 216 WP_000066484.1 cold shock-like protein CspB -
O6X69_RS04945 (993395) 993395..993607 + 213 WP_000087756.1 cold shock-like protein CspF -
O6X69_RS04950 (993662) 993662..993751 + 90 WP_120795389.1 hypothetical protein -
O6X69_RS04955 (994029) 994029..994781 - 753 WP_001047135.1 antitermination protein -
O6X69_RS04960 (994795) 994795..995844 - 1050 WP_001265198.1 DUF968 domain-containing protein -
O6X69_RS04965 (995846) 995846..996124 - 279 WP_012304870.1 hypothetical protein -
O6X69_RS04970 (996191) 996191..996442 - 252 WP_000980994.1 protein Rem -
O6X69_RS04975 (996659) 996659..996814 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
O6X69_RS04980 (996886) 996886..997173 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
O6X69_RS04985 (997173) 997173..997412 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
O6X69_RS04990 (997437) 997437..997742 + 306 WP_001326990.1 protein YdfV -
O6X69_RS04995 (997945) 997945..998277 + 333 WP_001301033.1 FlxA-like family protein -
O6X69_RS05000 (998714) 998714..998863 - 150 WP_011443592.1 protein YdfW -
O6X69_RS05005 (998898) 998898..999176 - 279 Protein_973 protein YdfX -
O6X69_RS05010 (999160) 999160..999390 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
O6X69_RS05015 (999474) 999474..999881 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
O6X69_RS05020 (1000048) 1000048..1000203 + 156 WP_000379575.1 DUF1391 family protein -
O6X69_RS05025 (1000205) 1000205..1000333 + 129 WP_000344964.1 protein YdfB -
O6X69_RS05030 (1000363) 1000363..1000581 + 219 WP_001171942.1 protein YdfC -
O6X69_RS05035 (1001149) 1001149..1001337 + 189 WP_000854559.1 cell division inhibition protein DicB -
O6X69_RS05040 (1001334) 1001334..1001525 + 192 WP_001083297.1 lysis protein YdfD -
O6X69_RS05045 (1001618) 1001618..1002385 + 768 Protein_981 exonuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 982542..1005584 23042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T266969 WP_000323025.1 NZ_CP114894:c997173-996886 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT266969 WP_000534858.1 NZ_CP114894:c997412-997173 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References