264399

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2245596..2246122 Replicon chromosome
Accession NZ_CP110859
Organism Escherichia coli strain TSW4881-W1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OQ464_RS10875 Protein ID WP_000323025.1
Coordinates 2245835..2246122 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OQ464_RS10870 Protein ID WP_000534858.1
Coordinates 2245596..2245835 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ464_RS10810 (2240623) 2240623..2241390 - 768 Protein_2113 exonuclease -
OQ464_RS10815 (2241483) 2241483..2241674 - 192 WP_001083297.1 lysis protein YdfD -
OQ464_RS10820 (2241671) 2241671..2241859 - 189 WP_000854559.1 cell division inhibition protein DicB -
OQ464_RS10825 (2242427) 2242427..2242645 - 219 WP_001171942.1 protein YdfC -
OQ464_RS10830 (2242675) 2242675..2242803 - 129 WP_000344964.1 protein YdfB -
OQ464_RS10835 (2242805) 2242805..2242960 - 156 WP_000379575.1 DUF1391 family protein -
OQ464_RS10840 (2243127) 2243127..2243534 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
OQ464_RS10845 (2243618) 2243618..2243848 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
OQ464_RS10850 (2243832) 2243832..2244110 + 279 Protein_2121 hypothetical protein -
OQ464_RS10855 (2244145) 2244145..2244294 + 150 WP_011443592.1 protein YdfW -
OQ464_RS10860 (2244731) 2244731..2245063 - 333 WP_001301033.1 FlxA-like family protein -
OQ464_RS10865 (2245266) 2245266..2245571 - 306 WP_001326990.1 protein YdfV -
OQ464_RS10870 (2245596) 2245596..2245835 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OQ464_RS10875 (2245835) 2245835..2246122 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OQ464_RS10880 (2246194) 2246194..2246349 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
OQ464_RS10885 (2246566) 2246566..2246817 + 252 WP_000980994.1 protein Rem -
OQ464_RS10890 (2246884) 2246884..2247162 + 279 WP_012304870.1 hypothetical protein -
OQ464_RS10895 (2247164) 2247164..2248213 + 1050 WP_001265198.1 DUF968 domain-containing protein -
OQ464_RS10900 (2248227) 2248227..2248979 + 753 WP_001047135.1 antitermination protein -
OQ464_RS10905 (2249257) 2249257..2249346 - 90 WP_120795389.1 hypothetical protein -
OQ464_RS10910 (2249401) 2249401..2249613 - 213 WP_000087756.1 cold shock-like protein CspF -
OQ464_RS10915 (2249914) 2249914..2250129 + 216 WP_000066484.1 cold shock-like protein CspB -
OQ464_RS10920 (2250493) 2250493..2250663 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
OQ464_RS10925 (2250883) 2250883..2251098 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2237424..2260466 23042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T264399 WP_000323025.1 NZ_CP110859:2245835-2246122 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT264399 WP_000534858.1 NZ_CP110859:2245596-2245835 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References