257660

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2233588..2234114 Replicon chromosome
Accession NZ_CP104330
Organism Escherichia coli strain THB42-F3

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag N0544_RS10800 Protein ID WP_000323025.1
Coordinates 2233827..2234114 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N0544_RS10795 Protein ID WP_000534858.1
Coordinates 2233588..2233827 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0544_RS10735 (2228615) 2228615..2229382 - 768 Protein_2095 exonuclease -
N0544_RS10740 (2229475) 2229475..2229666 - 192 WP_001083297.1 lysis protein YdfD -
N0544_RS10745 (2229663) 2229663..2229851 - 189 WP_000854559.1 cell division inhibition protein DicB -
N0544_RS10750 (2230419) 2230419..2230637 - 219 WP_001171942.1 protein YdfC -
N0544_RS10755 (2230667) 2230667..2230795 - 129 WP_000344964.1 protein YdfB -
N0544_RS10760 (2230797) 2230797..2230952 - 156 WP_000379575.1 DUF1391 family protein -
N0544_RS10765 (2231119) 2231119..2231526 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
N0544_RS10770 (2231610) 2231610..2231840 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
N0544_RS10775 (2231824) 2231824..2232102 + 279 Protein_2103 hypothetical protein -
N0544_RS10780 (2232137) 2232137..2232286 + 150 WP_011443592.1 protein YdfW -
N0544_RS10785 (2232723) 2232723..2233055 - 333 WP_001301033.1 FlxA-like family protein -
N0544_RS10790 (2233258) 2233258..2233563 - 306 WP_001326990.1 protein YdfV -
N0544_RS10795 (2233588) 2233588..2233827 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
N0544_RS10800 (2233827) 2233827..2234114 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
N0544_RS10805 (2234186) 2234186..2234341 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
N0544_RS10810 (2234558) 2234558..2234809 + 252 WP_000980994.1 protein Rem -
N0544_RS10815 (2234876) 2234876..2235154 + 279 WP_012304870.1 hypothetical protein -
N0544_RS10820 (2235156) 2235156..2236205 + 1050 WP_001265198.1 DUF968 domain-containing protein -
N0544_RS10825 (2236219) 2236219..2236971 + 753 WP_001047135.1 antitermination protein -
N0544_RS10830 (2237249) 2237249..2237338 - 90 WP_120795389.1 hypothetical protein -
N0544_RS10835 (2237393) 2237393..2237605 - 213 WP_000087756.1 cold shock-like protein CspF -
N0544_RS10840 (2237906) 2237906..2238121 + 216 WP_000066484.1 cold shock-like protein CspB -
N0544_RS10845 (2238485) 2238485..2238655 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
N0544_RS10850 (2238875) 2238875..2239090 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2226752..2250245 23493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T257660 WP_000323025.1 NZ_CP104330:2233827-2234114 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT257660 WP_000534858.1 NZ_CP104330:2233588-2233827 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References