160046

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1650163..1650689 Replicon chromosome
Accession NZ_CP054665
Organism Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HUR94_RS08220 Protein ID WP_000323025.1
Coordinates 1650163..1650450 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HUR94_RS08225 Protein ID WP_000534858.1
Coordinates 1650450..1650689 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR94_RS08170 (1645187) 1645187..1645402 - 216 WP_000839590.1 phage lysis protein EssD -
HUR94_RS08175 (1645622) 1645622..1645792 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
HUR94_RS08180 (1646156) 1646156..1646371 - 216 WP_000066484.1 cold shock-like protein CspB -
HUR94_RS08185 (1646672) 1646672..1646884 + 213 WP_000087756.1 cold shock-like protein CspF -
HUR94_RS08190 (1646939) 1646939..1647028 + 90 WP_120795389.1 hypothetical protein -
HUR94_RS08195 (1647306) 1647306..1648058 - 753 WP_001047135.1 antitermination protein -
HUR94_RS08200 (1648072) 1648072..1649121 - 1050 WP_001393597.1 DUF968 domain-containing protein -
HUR94_RS08205 (1649123) 1649123..1649401 - 279 WP_012304870.1 hypothetical protein -
HUR94_RS08210 (1649468) 1649468..1649719 - 252 WP_000980994.1 protein Rem -
HUR94_RS08215 (1649936) 1649936..1650091 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HUR94_RS08220 (1650163) 1650163..1650450 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HUR94_RS08225 (1650450) 1650450..1650689 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HUR94_RS08230 (1650714) 1650714..1651019 + 306 WP_001326990.1 protein YdfV -
HUR94_RS08235 (1651222) 1651222..1651554 + 333 WP_001301033.1 FlxA-like family protein -
HUR94_RS08240 (1651991) 1651991..1652140 - 150 WP_011443592.1 protein YdfW -
HUR94_RS08245 (1652175) 1652175..1652453 - 279 Protein_1605 hypothetical protein -
HUR94_RS08250 (1652437) 1652437..1652667 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
HUR94_RS08255 (1652751) 1652751..1653158 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
HUR94_RS08260 (1653325) 1653325..1653480 + 156 WP_000379575.1 DUF1391 family protein -
HUR94_RS22945 (1653482) 1653482..1653610 + 129 WP_000344964.1 protein YdfB -
HUR94_RS08265 (1653640) 1653640..1653858 + 219 WP_001171942.1 protein YdfC -
HUR94_RS08270 (1654426) 1654426..1654614 + 189 WP_000854559.1 cell division inhibition protein DicB -
HUR94_RS08275 (1654611) 1654611..1654802 + 192 WP_001083297.1 lysis protein YdfD -
HUR94_RS08280 (1654895) 1654895..1655662 + 768 Protein_1613 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1635819..1661561 25742


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T160046 WP_000323025.1 NZ_CP054665:c1650450-1650163 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T160046 NZ_CP070284:2446782-2446885 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT160046 WP_000534858.1 NZ_CP054665:c1650689-1650450 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT160046 NZ_CP070284:c2446887-2446655 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References