Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2078382..2078908 Replicon chromosome
Accession NZ_CP059043
Organism Escherichia coli strain SY3626C1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HZ987_RS10115 Protein ID WP_000323025.1
Coordinates 2078382..2078669 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HZ987_RS10120 Protein ID WP_000534858.1
Coordinates 2078669..2078908 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ987_RS10070 2073406..2073621 - 216 WP_000839590.1 phage lysis protein EssD -
HZ987_RS10075 2074375..2074590 - 216 WP_000066484.1 cold shock-like protein CspB -
HZ987_RS10080 2074891..2075103 + 213 WP_000087756.1 cold shock-like protein CspF -
HZ987_RS10085 2075158..2075247 + 90 WP_120795389.1 hypothetical protein -
HZ987_RS10090 2075525..2076277 - 753 WP_001047135.1 antitermination protein -
HZ987_RS10095 2076291..2077340 - 1050 WP_001265198.1 DUF968 domain-containing protein -
HZ987_RS10100 2077342..2077620 - 279 WP_012304870.1 hypothetical protein -
HZ987_RS10105 2077687..2077938 - 252 WP_000980994.1 hypothetical protein -
HZ987_RS10110 2078155..2078310 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HZ987_RS10115 2078382..2078669 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HZ987_RS10120 2078669..2078908 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HZ987_RS10125 2078933..2079238 + 306 WP_001326990.1 hypothetical protein -
HZ987_RS10130 2079441..2079773 + 333 WP_001301033.1 protein FlxA -
HZ987_RS10135 2080210..2080359 - 150 WP_011443592.1 hypothetical protein -
HZ987_RS10140 2080394..2080672 - 279 Protein_1986 hypothetical protein -
HZ987_RS10145 2080656..2080886 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
HZ987_RS10150 2080970..2081377 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
HZ987_RS10155 2081544..2081699 + 156 WP_000379575.1 DUF1391 family protein -
HZ987_RS10160 2081859..2082077 + 219 WP_001171942.1 hypothetical protein -
HZ987_RS10165 2082645..2082833 + 189 WP_000854559.1 cell division inhibition protein DicB -
HZ987_RS10170 2082830..2083021 + 192 WP_001083297.1 lysis protein YdfD -
HZ987_RS10175 2083114..2083881 + 768 Protein_1993 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2064038..2085744 21706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T168131 WP_000323025.1 NZ_CP059043:c2078669-2078382 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T168131 NZ_CP075640:c2993342-2993031 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT168131 WP_000534858.1 NZ_CP059043:c2078908-2078669 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT168131 NZ_CP075640:c2993030-2992740 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References