168131

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2078382..2078908 Replicon chromosome
Accession NZ_CP059043
Organism Escherichia coli strain SY3626C1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HZ987_RS10115 Protein ID WP_000323025.1
Coordinates 2078382..2078669 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HZ987_RS10120 Protein ID WP_000534858.1
Coordinates 2078669..2078908 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ987_RS10070 2073406..2073621 - 216 WP_000839590.1 phage lysis protein EssD -
HZ987_RS10075 2074375..2074590 - 216 WP_000066484.1 cold shock-like protein CspB -
HZ987_RS10080 2074891..2075103 + 213 WP_000087756.1 cold shock-like protein CspF -
HZ987_RS10085 2075158..2075247 + 90 WP_120795389.1 hypothetical protein -
HZ987_RS10090 2075525..2076277 - 753 WP_001047135.1 antitermination protein -
HZ987_RS10095 2076291..2077340 - 1050 WP_001265198.1 DUF968 domain-containing protein -
HZ987_RS10100 2077342..2077620 - 279 WP_012304870.1 hypothetical protein -
HZ987_RS10105 2077687..2077938 - 252 WP_000980994.1 hypothetical protein -
HZ987_RS10110 2078155..2078310 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HZ987_RS10115 2078382..2078669 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HZ987_RS10120 2078669..2078908 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HZ987_RS10125 2078933..2079238 + 306 WP_001326990.1 hypothetical protein -
HZ987_RS10130 2079441..2079773 + 333 WP_001301033.1 protein FlxA -
HZ987_RS10135 2080210..2080359 - 150 WP_011443592.1 hypothetical protein -
HZ987_RS10140 2080394..2080672 - 279 Protein_1986 hypothetical protein -
HZ987_RS10145 2080656..2080886 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
HZ987_RS10150 2080970..2081377 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
HZ987_RS10155 2081544..2081699 + 156 WP_000379575.1 DUF1391 family protein -
HZ987_RS10160 2081859..2082077 + 219 WP_001171942.1 hypothetical protein -
HZ987_RS10165 2082645..2082833 + 189 WP_000854559.1 cell division inhibition protein DicB -
HZ987_RS10170 2082830..2083021 + 192 WP_001083297.1 lysis protein YdfD -
HZ987_RS10175 2083114..2083881 + 768 Protein_1993 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2064038..2085744 21706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T168131 WP_000323025.1 NZ_CP059043:c2078669-2078382 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T168131 NZ_CP075640:c2993342-2993031 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT168131 WP_000534858.1 NZ_CP059043:c2078908-2078669 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT168131 NZ_CP075640:c2993030-2992740 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References