Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1649000..1649526 Replicon chromosome
Accession NZ_LT615378
Organism Escherichia coli isolate 103

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag BV310_RS08870 Protein ID WP_000323025.1
Coordinates 1649000..1649287 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag BV310_RS08875 Protein ID WP_000534858.1
Coordinates 1649287..1649526 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV310_RS08830 1644024..1644239 - 216 WP_000839590.1 phage lysis protein EssD -
BV310_RS25555 1644459..1644629 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
BV310_RS08835 1644993..1645208 - 216 WP_000066484.1 cold shock-like protein CspB -
BV310_RS08840 1645509..1645721 + 213 WP_000087756.1 cold shock-like protein CspF -
BV310_RS25120 1645776..1645865 + 90 WP_120795389.1 hypothetical protein -
BV310_RS08845 1646143..1646895 - 753 WP_001047135.1 antitermination protein -
BV310_RS08850 1646909..1647958 - 1050 WP_075320780.1 DUF968 domain-containing protein -
BV310_RS08855 1647960..1648238 - 279 WP_012304870.1 hypothetical protein -
BV310_RS08860 1648305..1648556 - 252 WP_000980994.1 hypothetical protein -
BV310_RS08865 1648773..1648928 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
BV310_RS08870 1649000..1649287 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
BV310_RS08875 1649287..1649526 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
BV310_RS08880 1649551..1649856 + 306 WP_001326990.1 hypothetical protein -
BV310_RS08890 1650059..1650391 + 333 WP_001301033.1 protein FlxA -
BV310_RS08895 1650828..1650977 - 150 WP_011443592.1 hypothetical protein -
BV310_RS08900 1651012..1651290 - 279 Protein_1588 hypothetical protein -
BV310_RS08905 1651274..1651504 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
BV310_RS08910 1651588..1651995 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
BV310_RS08915 1652162..1652317 + 156 WP_000379575.1 DUF1391 family protein -
BV310_RS08925 1652477..1652695 + 219 WP_001171942.1 hypothetical protein -
BV310_RS08935 1653263..1653451 + 189 WP_000854559.1 cell division inhibition protein DicB -
BV310_RS08940 1653448..1653639 + 192 WP_001083297.1 lysis protein YdfD -
BV310_RS08945 1653732..1654499 + 768 Protein_1595 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1634656..1668117 33461
inside Prophage - - 1634656..1661524 26868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T293374 WP_000323025.1 NZ_LT615378:c1649287-1649000 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT293374 WP_000534858.1 NZ_LT615378:c1649526-1649287 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References