137913

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2117201..2117727 Replicon chromosome
Accession NZ_CP043213
Organism Escherichia coli O16:H48 strain CV601gfp

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FYA04_RS10440 Protein ID WP_000323025.1
Coordinates 2117201..2117488 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FYA04_RS10445 Protein ID WP_000534858.1
Coordinates 2117488..2117727 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA04_RS10395 2112225..2112440 - 216 WP_000839590.1 phage lysis protein EssD -
FYA04_RS23085 2112660..2112830 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
FYA04_RS10400 2113194..2113409 - 216 WP_000066484.1 cold shock-like protein CspB -
FYA04_RS10405 2113710..2113922 + 213 WP_000087756.1 cold shock-like protein CspF -
FYA04_RS10410 2113977..2114066 + 90 WP_120795389.1 hypothetical protein -
FYA04_RS10415 2114344..2115096 - 753 WP_001047135.1 antitermination protein -
FYA04_RS10420 2115110..2116159 - 1050 WP_001265198.1 DUF968 domain-containing protein -
FYA04_RS10425 2116161..2116439 - 279 WP_012304870.1 hypothetical protein -
FYA04_RS10430 2116506..2116757 - 252 WP_000980994.1 hypothetical protein -
FYA04_RS10435 2116974..2117129 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FYA04_RS10440 2117201..2117488 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FYA04_RS10445 2117488..2117727 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FYA04_RS10450 2117752..2118057 + 306 WP_001326990.1 hypothetical protein -
FYA04_RS10455 2118260..2118592 + 333 WP_001301033.1 protein FlxA -
FYA04_RS10460 2119029..2119178 - 150 WP_011443592.1 hypothetical protein -
FYA04_RS10465 2119213..2119491 - 279 Protein_2044 hypothetical protein -
FYA04_RS10470 2119475..2119705 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
FYA04_RS10475 2119789..2120196 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FYA04_RS10480 2120363..2120518 + 156 WP_000379575.1 DUF1391 family protein -
FYA04_RS10485 2120678..2120896 + 219 WP_001171942.1 hypothetical protein -
FYA04_RS10495 2121464..2121652 + 189 WP_000854559.1 cell division inhibition protein DicB -
FYA04_RS10500 2121649..2121840 + 192 WP_001083297.1 lysis protein YdfD -
FYA04_RS10505 2121933..2122700 + 768 Protein_2051 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2102857..2124563 21706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T137913 WP_000323025.1 NZ_CP043213:c2117488-2117201 [Escherichia coli O16:H48]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T137913 NZ_CP043213:c2117488-2117201 [Escherichia coli O16:H48]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT137913 WP_000534858.1 NZ_CP043213:c2117727-2117488 [Escherichia coli O16:H48]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT137913 NZ_CP043213:c2117727-2117488 [Escherichia coli O16:H48]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References