276777

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4081197..4081723 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QCG47_RS19815 Protein ID WP_000323025.1
Coordinates 4081197..4081484 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QCG47_RS19820 Protein ID WP_000534858.1
Coordinates 4081484..4081723 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS19765 (4076221) 4076221..4076436 - 216 WP_000839590.1 phage lysis protein EssD -
QCG47_RS19770 (4076656) 4076656..4076826 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
QCG47_RS19775 (4077190) 4077190..4077405 - 216 WP_000066484.1 cold shock-like protein CspB -
QCG47_RS19780 (4077706) 4077706..4077918 + 213 WP_000087756.1 cold shock-like protein CspF -
QCG47_RS19785 (4077973) 4077973..4078062 + 90 WP_120795389.1 hypothetical protein -
QCG47_RS19790 (4078340) 4078340..4079092 - 753 WP_001047135.1 antitermination protein -
QCG47_RS19795 (4079106) 4079106..4080155 - 1050 WP_001393597.1 DUF968 domain-containing protein -
QCG47_RS19800 (4080157) 4080157..4080435 - 279 WP_012304870.1 hypothetical protein -
QCG47_RS19805 (4080502) 4080502..4080753 - 252 WP_000980994.1 protein Rem -
QCG47_RS19810 (4080970) 4080970..4081125 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QCG47_RS19815 (4081197) 4081197..4081484 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QCG47_RS19820 (4081484) 4081484..4081723 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QCG47_RS19825 (4081748) 4081748..4082053 + 306 WP_001326990.1 protein YdfV -
QCG47_RS19830 (4082256) 4082256..4082588 + 333 WP_001301033.1 FlxA-like family protein -
QCG47_RS19835 (4083025) 4083025..4083174 - 150 WP_011443592.1 protein YdfW -
QCG47_RS19840 (4083209) 4083209..4083487 - 279 Protein_3856 protein YdfX -
QCG47_RS19845 (4083471) 4083471..4083701 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
QCG47_RS19850 (4083785) 4083785..4084192 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
QCG47_RS19855 (4084359) 4084359..4084514 + 156 WP_000379575.1 DUF1391 family protein -
QCG47_RS19860 (4084516) 4084516..4084644 + 129 WP_000344964.1 protein YdfB -
QCG47_RS19865 (4084674) 4084674..4084892 + 219 WP_001171942.1 protein YdfC -
QCG47_RS19870 (4085460) 4085460..4085648 + 189 WP_000854559.1 cell division inhibition protein DicB -
QCG47_RS19875 (4085645) 4085645..4085836 + 192 WP_001083297.1 lysis protein YdfD -
QCG47_RS19880 (4085929) 4085929..4086696 + 768 Protein_3864 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4066853..4089766 22913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T276777 WP_000323025.1 NZ_CP122319:c4081484-4081197 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT276777 WP_000534858.1 NZ_CP122319:c4081723-4081484 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References