102958

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2078674..2079200 Replicon chromosome
Accession NZ_CP028702
Organism Escherichia coli strain J53

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag DBB46_RS10910 Protein ID WP_000323025.1
Coordinates 2078674..2078961 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag DBB46_RS10915 Protein ID WP_000534858.1
Coordinates 2078961..2079200 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBB46_RS10870 2073698..2073913 - 216 WP_000839590.1 phage lysis protein EssD -
DBB46_RS24685 2074133..2074303 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
DBB46_RS10875 2074667..2074882 - 216 WP_000066484.1 cold shock-like protein CspB -
DBB46_RS10880 2075183..2075395 + 213 WP_000087756.1 cold shock-like protein CspF -
DBB46_RS24430 2075450..2075539 + 90 WP_120795389.1 hypothetical protein -
DBB46_RS10885 2075817..2076569 - 753 WP_001047135.1 antitermination protein -
DBB46_RS10890 2076583..2077632 - 1050 WP_001265198.1 DUF968 domain-containing protein -
DBB46_RS10895 2077634..2077912 - 279 WP_012304870.1 hypothetical protein -
DBB46_RS10900 2077979..2078230 - 252 WP_000980994.1 hypothetical protein -
DBB46_RS10905 2078447..2078602 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
DBB46_RS10910 2078674..2078961 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DBB46_RS10915 2078961..2079200 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DBB46_RS10920 2079225..2079530 + 306 WP_001326990.1 hypothetical protein -
DBB46_RS10925 2079733..2080065 + 333 WP_001301033.1 protein FlxA -
DBB46_RS24435 2080502..2080651 - 150 WP_011443592.1 hypothetical protein -
DBB46_RS10935 2080686..2080964 - 279 Protein_1999 hypothetical protein -
DBB46_RS10940 2080948..2081178 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
DBB46_RS10945 2081262..2081669 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
DBB46_RS10950 2081836..2081991 + 156 WP_000379575.1 DUF1391 family protein -
DBB46_RS10960 2082151..2082369 + 219 WP_001171942.1 hypothetical protein -
DBB46_RS10970 2082937..2083125 + 189 WP_000854559.1 cell division inhibition protein DicB -
DBB46_RS10975 2083122..2083313 + 192 WP_001083297.1 lysis protein YdfD -
DBB46_RS10980 2083406..2084173 + 768 Protein_2006 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2064330..2086036 21706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T102958 WP_000323025.1 NZ_CP028702:c2078961-2078674 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T102958 NZ_CP028702:c2078961-2078674 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT102958 WP_000534858.1 NZ_CP028702:c2079200-2078961 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT102958 NZ_CP028702:c2079200-2078961 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References