Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 374941..375467 Replicon chromosome
Accession NZ_CP043185
Organism Escherichia coli O16:H48 strain PG20180171

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FYA18_RS01860 Protein ID WP_000323025.1
Coordinates 374941..375228 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FYA18_RS01865 Protein ID WP_000534858.1
Coordinates 375228..375467 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA18_RS01815 369965..370180 - 216 WP_000839590.1 phage lysis protein EssD -
FYA18_RS22735 370400..370570 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
FYA18_RS01820 370934..371149 - 216 WP_000066484.1 cold shock-like protein CspB -
FYA18_RS01825 371450..371662 + 213 WP_000087756.1 cold shock-like protein CspF -
FYA18_RS01830 371717..371806 + 90 WP_120795389.1 hypothetical protein -
FYA18_RS01835 372084..372836 - 753 WP_001047135.1 antitermination protein -
FYA18_RS01840 372850..373899 - 1050 WP_001265198.1 DUF968 domain-containing protein -
FYA18_RS01845 373901..374179 - 279 WP_012304870.1 hypothetical protein -
FYA18_RS01850 374246..374497 - 252 WP_000980994.1 hypothetical protein -
FYA18_RS01855 374714..374869 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FYA18_RS01860 374941..375228 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FYA18_RS01865 375228..375467 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FYA18_RS01870 375492..375797 + 306 WP_001326990.1 hypothetical protein -
FYA18_RS01875 376000..376332 + 333 WP_001301033.1 protein FlxA -
FYA18_RS01880 376769..376918 - 150 WP_011443592.1 hypothetical protein -
FYA18_RS01885 376953..377231 - 279 Protein_373 hypothetical protein -
FYA18_RS01890 377215..377445 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
FYA18_RS01895 377529..377936 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FYA18_RS01900 378103..378258 + 156 WP_000379575.1 DUF1391 family protein -
FYA18_RS01905 378418..378636 + 219 WP_001171942.1 hypothetical protein -
FYA18_RS01915 379204..379392 + 189 WP_000854559.1 cell division inhibition protein DicB -
FYA18_RS01920 379389..379580 + 192 WP_001083297.1 lysis protein YdfD -
FYA18_RS01925 379673..380440 + 768 Protein_380 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 360597..386339 25742


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T137428 WP_000323025.1 NZ_CP043185:c375228-374941 [Escherichia coli O16:H48]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T137428 NZ_CP056737:c1237388-1237026 [Enterobacter roggenkampii]
ATGTGGAACGTCGAGACAACGGACAGATTTGACGACTGGTTCTTTGAACAAACAACAGCATTAAAAGAAGATGTGCTGGC
GACGATGCATATTCTTGCTGAATTTGGCCCAACCCTGGGGCGACCATACGTAGACACCGTGAAGGATTCAGCCTATGCGA
ACATGAAAGAGTTACGTATTCAGCATGCGGGTAATCCCATCAGAGCCTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAGACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATCGTGCTGGCTGACGTTGAATA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT137428 WP_000534858.1 NZ_CP043185:c375467-375228 [Escherichia coli O16:H48]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT137428 NZ_CP056737:c1237038-1236739 [Enterobacter roggenkampii]
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCGCGGAAAGTCAGGAGCGTATAGCGGCTAAAGTTGAAGTGATGCG
CAGAATTGTTGCCCTGAACCAGCTGCGGGAAGAGCTCAATATTTCCCAGACAGAACTGGCCGCAGCAATGGGGGTAAAAC
AACCCACTTTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGCTACCGAATGGGAAACGGATAGCGTTTCAGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References