137428

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 374941..375467 Replicon chromosome
Accession NZ_CP043185
Organism Escherichia coli O16:H48 strain PG20180171

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FYA18_RS01860 Protein ID WP_000323025.1
Coordinates 374941..375228 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FYA18_RS01865 Protein ID WP_000534858.1
Coordinates 375228..375467 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA18_RS01815 369965..370180 - 216 WP_000839590.1 phage lysis protein EssD -
FYA18_RS22735 370400..370570 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
FYA18_RS01820 370934..371149 - 216 WP_000066484.1 cold shock-like protein CspB -
FYA18_RS01825 371450..371662 + 213 WP_000087756.1 cold shock-like protein CspF -
FYA18_RS01830 371717..371806 + 90 WP_120795389.1 hypothetical protein -
FYA18_RS01835 372084..372836 - 753 WP_001047135.1 antitermination protein -
FYA18_RS01840 372850..373899 - 1050 WP_001265198.1 DUF968 domain-containing protein -
FYA18_RS01845 373901..374179 - 279 WP_012304870.1 hypothetical protein -
FYA18_RS01850 374246..374497 - 252 WP_000980994.1 hypothetical protein -
FYA18_RS01855 374714..374869 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FYA18_RS01860 374941..375228 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FYA18_RS01865 375228..375467 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FYA18_RS01870 375492..375797 + 306 WP_001326990.1 hypothetical protein -
FYA18_RS01875 376000..376332 + 333 WP_001301033.1 protein FlxA -
FYA18_RS01880 376769..376918 - 150 WP_011443592.1 hypothetical protein -
FYA18_RS01885 376953..377231 - 279 Protein_373 hypothetical protein -
FYA18_RS01890 377215..377445 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
FYA18_RS01895 377529..377936 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FYA18_RS01900 378103..378258 + 156 WP_000379575.1 DUF1391 family protein -
FYA18_RS01905 378418..378636 + 219 WP_001171942.1 hypothetical protein -
FYA18_RS01915 379204..379392 + 189 WP_000854559.1 cell division inhibition protein DicB -
FYA18_RS01920 379389..379580 + 192 WP_001083297.1 lysis protein YdfD -
FYA18_RS01925 379673..380440 + 768 Protein_380 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 360597..386339 25742


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T137428 WP_000323025.1 NZ_CP043185:c375228-374941 [Escherichia coli O16:H48]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T137428 NZ_CP056737:c1237388-1237026 [Enterobacter roggenkampii]
ATGTGGAACGTCGAGACAACGGACAGATTTGACGACTGGTTCTTTGAACAAACAACAGCATTAAAAGAAGATGTGCTGGC
GACGATGCATATTCTTGCTGAATTTGGCCCAACCCTGGGGCGACCATACGTAGACACCGTGAAGGATTCAGCCTATGCGA
ACATGAAAGAGTTACGTATTCAGCATGCGGGTAATCCCATCAGAGCCTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAGACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATCGTGCTGGCTGACGTTGAATA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT137428 WP_000534858.1 NZ_CP043185:c375467-375228 [Escherichia coli O16:H48]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT137428 NZ_CP056737:c1237038-1236739 [Enterobacter roggenkampii]
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCGCGGAAAGTCAGGAGCGTATAGCGGCTAAAGTTGAAGTGATGCG
CAGAATTGTTGCCCTGAACCAGCTGCGGGAAGAGCTCAATATTTCCCAGACAGAACTGGCCGCAGCAATGGGGGTAAAAC
AACCCACTTTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGCTACCGAATGGGAAACGGATAGCGTTTCAGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References