257630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2233891..2234417 Replicon chromosome
Accession NZ_CP104328
Organism Escherichia coli strain THB42-F2

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag N0499_RS10800 Protein ID WP_000323025.1
Coordinates 2234130..2234417 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N0499_RS10795 Protein ID WP_000534858.1
Coordinates 2233891..2234130 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0499_RS10735 (2228918) 2228918..2229685 - 768 Protein_2095 exonuclease -
N0499_RS10740 (2229778) 2229778..2229969 - 192 WP_001083297.1 lysis protein YdfD -
N0499_RS10745 (2229966) 2229966..2230154 - 189 WP_000854559.1 cell division inhibition protein DicB -
N0499_RS10750 (2230722) 2230722..2230940 - 219 WP_001171942.1 protein YdfC -
N0499_RS10755 (2230970) 2230970..2231098 - 129 WP_000344964.1 protein YdfB -
N0499_RS10760 (2231100) 2231100..2231255 - 156 WP_000379575.1 DUF1391 family protein -
N0499_RS10765 (2231422) 2231422..2231829 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
N0499_RS10770 (2231913) 2231913..2232143 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
N0499_RS10775 (2232127) 2232127..2232405 + 279 Protein_2103 hypothetical protein -
N0499_RS10780 (2232440) 2232440..2232589 + 150 WP_011443592.1 protein YdfW -
N0499_RS10785 (2233026) 2233026..2233358 - 333 WP_001301033.1 FlxA-like family protein -
N0499_RS10790 (2233561) 2233561..2233866 - 306 WP_001326990.1 protein YdfV -
N0499_RS10795 (2233891) 2233891..2234130 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
N0499_RS10800 (2234130) 2234130..2234417 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
N0499_RS10805 (2234489) 2234489..2234644 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
N0499_RS10810 (2234861) 2234861..2235112 + 252 WP_000980994.1 protein Rem -
N0499_RS10815 (2235179) 2235179..2235457 + 279 WP_012304870.1 hypothetical protein -
N0499_RS10820 (2235459) 2235459..2236508 + 1050 WP_001265198.1 DUF968 domain-containing protein -
N0499_RS10825 (2236522) 2236522..2237274 + 753 WP_001047135.1 antitermination protein -
N0499_RS10830 (2237552) 2237552..2237641 - 90 WP_120795389.1 hypothetical protein -
N0499_RS10835 (2237696) 2237696..2237908 - 213 WP_000087756.1 cold shock-like protein CspF -
N0499_RS10840 (2238209) 2238209..2238424 + 216 WP_000066484.1 cold shock-like protein CspB -
N0499_RS10845 (2238788) 2238788..2238958 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
N0499_RS10850 (2239178) 2239178..2239393 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2227055..2248761 21706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T257630 WP_000323025.1 NZ_CP104328:2234130-2234417 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT257630 WP_000534858.1 NZ_CP104328:2233891-2234130 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References