Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2233588..2234114 Replicon chromosome
Accession NZ_CP110816
Organism Escherichia coli strain THB42-F5

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag N0566_RS10800 Protein ID WP_000323025.1
Coordinates 2233827..2234114 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N0566_RS10795 Protein ID WP_000534858.1
Coordinates 2233588..2233827 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0566_RS10735 (2228615) 2228615..2229382 - 768 Protein_2095 exonuclease -
N0566_RS10740 (2229475) 2229475..2229666 - 192 WP_001083297.1 lysis protein YdfD -
N0566_RS10745 (2229663) 2229663..2229851 - 189 WP_000854559.1 cell division inhibition protein DicB -
N0566_RS10750 (2230419) 2230419..2230637 - 219 WP_001171942.1 protein YdfC -
N0566_RS10755 (2230667) 2230667..2230795 - 129 WP_000344964.1 protein YdfB -
N0566_RS10760 (2230797) 2230797..2230952 - 156 WP_000379575.1 DUF1391 family protein -
N0566_RS10765 (2231119) 2231119..2231526 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
N0566_RS10770 (2231610) 2231610..2231840 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
N0566_RS10775 (2231824) 2231824..2232102 + 279 Protein_2103 hypothetical protein -
N0566_RS10780 (2232137) 2232137..2232286 + 150 WP_011443592.1 protein YdfW -
N0566_RS10785 (2232723) 2232723..2233055 - 333 WP_001301033.1 FlxA-like family protein -
N0566_RS10790 (2233258) 2233258..2233563 - 306 WP_001326990.1 protein YdfV -
N0566_RS10795 (2233588) 2233588..2233827 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
N0566_RS10800 (2233827) 2233827..2234114 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
N0566_RS10805 (2234186) 2234186..2234341 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
N0566_RS10810 (2234558) 2234558..2234809 + 252 WP_000980994.1 protein Rem -
N0566_RS10815 (2234876) 2234876..2235154 + 279 WP_012304870.1 hypothetical protein -
N0566_RS10820 (2235156) 2235156..2236205 + 1050 WP_001265198.1 DUF968 domain-containing protein -
N0566_RS10825 (2236219) 2236219..2236971 + 753 WP_001047135.1 antitermination protein -
N0566_RS10830 (2237249) 2237249..2237338 - 90 WP_120795389.1 hypothetical protein -
N0566_RS10835 (2237393) 2237393..2237605 - 213 WP_000087756.1 cold shock-like protein CspF -
N0566_RS10840 (2237906) 2237906..2238121 + 216 WP_000066484.1 cold shock-like protein CspB -
N0566_RS10845 (2238485) 2238485..2238655 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
N0566_RS10850 (2238875) 2238875..2239090 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2226752..2250245 23493
inside Prophage - - 2226752..2251108 24356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T264338 WP_000323025.1 NZ_CP110816:2233827-2234114 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT264338 WP_000534858.1 NZ_CP110816:2233588-2233827 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References