205629

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1603278..1603804 Replicon chromosome
Accession NZ_CP076404
Organism Escherichia coli strain K-12 substr. AB1157

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KJY95_RS07830 Protein ID WP_000323025.1
Coordinates 1603278..1603565 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KJY95_RS07835 Protein ID WP_000534858.1
Coordinates 1603565..1603804 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJY95_RS07780 (1598302) 1598302..1598517 - 216 WP_000839590.1 phage lysis protein EssD -
KJY95_RS07785 (1598737) 1598737..1598907 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
KJY95_RS07790 (1599271) 1599271..1599486 - 216 WP_000066484.1 cold shock-like protein CspB -
KJY95_RS07795 (1599787) 1599787..1599999 + 213 WP_000087756.1 cold shock-like protein CspF -
KJY95_RS07800 (1600054) 1600054..1600143 + 90 WP_120795389.1 hypothetical protein -
KJY95_RS07805 (1600421) 1600421..1601173 - 753 WP_001047135.1 antitermination protein -
KJY95_RS07810 (1601187) 1601187..1602236 - 1050 WP_001265198.1 DUF968 domain-containing protein -
KJY95_RS07815 (1602238) 1602238..1602516 - 279 WP_012304870.1 hypothetical protein -
KJY95_RS07820 (1602583) 1602583..1602834 - 252 WP_000980994.1 protein Rem -
KJY95_RS07825 (1603051) 1603051..1603206 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KJY95_RS07830 (1603278) 1603278..1603565 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KJY95_RS07835 (1603565) 1603565..1603804 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KJY95_RS07840 (1603829) 1603829..1604134 + 306 WP_001326990.1 protein YdfV -
KJY95_RS07845 (1604337) 1604337..1604669 + 333 WP_001301033.1 FlxA-like family protein -
KJY95_RS07850 (1605106) 1605106..1605255 - 150 WP_011443592.1 protein YdfW -
KJY95_RS07855 (1605290) 1605290..1605568 - 279 Protein_1537 hypothetical protein -
KJY95_RS07860 (1605552) 1605552..1605782 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
KJY95_RS07865 (1605866) 1605866..1606273 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
KJY95_RS07870 (1606440) 1606440..1606595 + 156 WP_000379575.1 DUF1391 family protein -
KJY95_RS22210 (1606597) 1606597..1606725 + 129 WP_000344964.1 protein YdfB -
KJY95_RS07875 (1606755) 1606755..1606973 + 219 WP_001171942.1 protein YdfC -
KJY95_RS07880 (1607541) 1607541..1607729 + 189 WP_000854559.1 cell division inhibition protein DicB -
KJY95_RS07885 (1607726) 1607726..1607917 + 192 WP_001083297.1 lysis protein YdfD -
KJY95_RS07890 (1608010) 1608010..1608777 + 768 Protein_1545 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1588934..1610640 21706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T205629 WP_000323025.1 NZ_CP076404:c1603565-1603278 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T205629 NZ_CP101776:4159647-4159865 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT205629 WP_000534858.1 NZ_CP076404:c1603804-1603565 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT205629 NZ_CP101776:4159246-4159620 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References