276688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 176857..177383 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QCG49_RS00860 Protein ID WP_000323025.1
Coordinates 176857..177144 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QCG49_RS00865 Protein ID WP_000534858.1
Coordinates 177144..177383 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS00810 (171881) 171881..172096 - 216 WP_000839590.1 phage lysis protein EssD -
QCG49_RS00815 (172316) 172316..172486 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
QCG49_RS00820 (172850) 172850..173065 - 216 WP_000066484.1 cold shock-like protein CspB -
QCG49_RS00825 (173366) 173366..173578 + 213 WP_000087756.1 cold shock-like protein CspF -
QCG49_RS00830 (173633) 173633..173722 + 90 WP_120795389.1 hypothetical protein -
QCG49_RS00835 (174000) 174000..174752 - 753 WP_001047135.1 antitermination protein -
QCG49_RS00840 (174766) 174766..175815 - 1050 WP_001393597.1 DUF968 domain-containing protein -
QCG49_RS00845 (175817) 175817..176095 - 279 WP_012304870.1 hypothetical protein -
QCG49_RS00850 (176162) 176162..176413 - 252 WP_000980994.1 protein Rem -
QCG49_RS00855 (176630) 176630..176785 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QCG49_RS00860 (176857) 176857..177144 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QCG49_RS00865 (177144) 177144..177383 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QCG49_RS00870 (177408) 177408..177713 + 306 WP_001326990.1 protein YdfV -
QCG49_RS00875 (177916) 177916..178248 + 333 WP_001301033.1 FlxA-like family protein -
QCG49_RS00880 (178685) 178685..178834 - 150 WP_011443592.1 protein YdfW -
QCG49_RS00885 (178869) 178869..179147 - 279 Protein_176 protein YdfX -
QCG49_RS00890 (179131) 179131..179361 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
QCG49_RS00895 (179445) 179445..179852 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
QCG49_RS00900 (180019) 180019..180174 + 156 WP_000379575.1 DUF1391 family protein -
QCG49_RS00905 (180176) 180176..180304 + 129 WP_000344964.1 protein YdfB -
QCG49_RS00910 (180334) 180334..180552 + 219 WP_001171942.1 protein YdfC -
QCG49_RS00915 (181120) 181120..181308 + 189 WP_000854559.1 cell division inhibition protein DicB -
QCG49_RS00920 (181305) 181305..181496 + 192 WP_001083297.1 lysis protein YdfD -
QCG49_RS00925 (181589) 181589..182356 + 768 Protein_184 exonuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 162513..184219 21706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T276688 WP_000323025.1 NZ_CP122317:c177144-176857 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT276688 WP_000534858.1 NZ_CP122317:c177383-177144 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References