157065

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1629391..1629917 Replicon chromosome
Accession NZ_CP053603
Organism Escherichia coli strain Dam/Dcm

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HO395_RS07900 Protein ID WP_000323025.1
Coordinates 1629391..1629678 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HO395_RS07905 Protein ID WP_000534858.1
Coordinates 1629678..1629917 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO395_RS07855 1624415..1624630 - 216 WP_000839590.1 phage lysis protein EssD -
HO395_RS07860 1625384..1625599 - 216 WP_000066484.1 cold shock-like protein CspB -
HO395_RS07865 1625900..1626112 + 213 WP_000087756.1 cold shock-like protein CspF -
HO395_RS07870 1626167..1626256 + 90 WP_120795389.1 hypothetical protein -
HO395_RS07875 1626534..1627286 - 753 WP_001047135.1 antitermination protein -
HO395_RS07880 1627300..1628349 - 1050 WP_001265198.1 DUF968 domain-containing protein -
HO395_RS07885 1628351..1628629 - 279 WP_012304870.1 hypothetical protein -
HO395_RS07890 1628696..1628947 - 252 WP_000980994.1 hypothetical protein -
HO395_RS07895 1629164..1629319 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HO395_RS07900 1629391..1629678 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HO395_RS07905 1629678..1629917 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HO395_RS07910 1629942..1630247 + 306 WP_001326990.1 hypothetical protein -
HO395_RS07915 1630450..1630782 + 333 WP_001301033.1 protein FlxA -
HO395_RS07920 1631219..1631368 - 150 WP_011443592.1 hypothetical protein -
HO395_RS07925 1631403..1631681 - 279 Protein_1548 hypothetical protein -
HO395_RS07930 1631665..1631895 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
HO395_RS07935 1631979..1632386 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
HO395_RS07940 1632553..1632708 + 156 WP_000379575.1 DUF1391 family protein -
HO395_RS07945 1632868..1633086 + 219 WP_001171942.1 hypothetical protein -
HO395_RS07950 1633090..1633254 - 165 WP_014639039.1 hypothetical protein -
HO395_RS07955 1633654..1633842 + 189 WP_000854559.1 cell division inhibition protein DicB -
HO395_RS07960 1633839..1634030 + 192 WP_001083297.1 lysis protein YdfD -
HO395_RS07965 1634123..1634890 + 768 Protein_1556 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1615047..1641915 26868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T157065 WP_000323025.1 NZ_CP053603:c1629678-1629391 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T157065 NZ_CP069075:3190634-3191077 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT157065 WP_000534858.1 NZ_CP053603:c1629917-1629678 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT157065 NZ_CP069075:3190390-3190647 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References