Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1629391..1629917 Replicon chromosome
Accession NZ_CP053603
Organism Escherichia coli strain Dam/Dcm

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HO395_RS07900 Protein ID WP_000323025.1
Coordinates 1629391..1629678 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HO395_RS07905 Protein ID WP_000534858.1
Coordinates 1629678..1629917 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO395_RS07855 1624415..1624630 - 216 WP_000839590.1 phage lysis protein EssD -
HO395_RS07860 1625384..1625599 - 216 WP_000066484.1 cold shock-like protein CspB -
HO395_RS07865 1625900..1626112 + 213 WP_000087756.1 cold shock-like protein CspF -
HO395_RS07870 1626167..1626256 + 90 WP_120795389.1 hypothetical protein -
HO395_RS07875 1626534..1627286 - 753 WP_001047135.1 antitermination protein -
HO395_RS07880 1627300..1628349 - 1050 WP_001265198.1 DUF968 domain-containing protein -
HO395_RS07885 1628351..1628629 - 279 WP_012304870.1 hypothetical protein -
HO395_RS07890 1628696..1628947 - 252 WP_000980994.1 hypothetical protein -
HO395_RS07895 1629164..1629319 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HO395_RS07900 1629391..1629678 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HO395_RS07905 1629678..1629917 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HO395_RS07910 1629942..1630247 + 306 WP_001326990.1 hypothetical protein -
HO395_RS07915 1630450..1630782 + 333 WP_001301033.1 protein FlxA -
HO395_RS07920 1631219..1631368 - 150 WP_011443592.1 hypothetical protein -
HO395_RS07925 1631403..1631681 - 279 Protein_1548 hypothetical protein -
HO395_RS07930 1631665..1631895 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
HO395_RS07935 1631979..1632386 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
HO395_RS07940 1632553..1632708 + 156 WP_000379575.1 DUF1391 family protein -
HO395_RS07945 1632868..1633086 + 219 WP_001171942.1 hypothetical protein -
HO395_RS07950 1633090..1633254 - 165 WP_014639039.1 hypothetical protein -
HO395_RS07955 1633654..1633842 + 189 WP_000854559.1 cell division inhibition protein DicB -
HO395_RS07960 1633839..1634030 + 192 WP_001083297.1 lysis protein YdfD -
HO395_RS07965 1634123..1634890 + 768 Protein_1556 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1615047..1641915 26868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T157065 WP_000323025.1 NZ_CP053603:c1629678-1629391 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T157065 NZ_CP069075:3190634-3191077 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT157065 WP_000534858.1 NZ_CP053603:c1629917-1629678 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT157065 NZ_CP069075:3190390-3190647 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References