49364

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1627112..1627638 Replicon chromosome
Accession NZ_CP009644
Organism Escherichia coli ER2796 strain K-12 ER2796

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ER2796_RS08100 Protein ID WP_000323025.1
Coordinates 1627112..1627399 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ER2796_RS08105 Protein ID WP_000534858.1
Coordinates 1627399..1627638 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER2796_RS08060 1622136..1622351 - 216 WP_000839590.1 phage lysis protein EssD -
ER2796_RS08065 1623105..1623320 - 216 WP_000066484.1 cold shock-like protein CspB -
ER2796_RS08070 1623621..1623833 + 213 WP_000087756.1 cold shock-like protein CspF -
ER2796_RS25315 1623888..1623977 + 90 WP_120795389.1 hypothetical protein -
ER2796_RS08075 1624255..1625007 - 753 WP_001047135.1 antitermination protein -
ER2796_RS08080 1625021..1626070 - 1050 WP_001265198.1 DUF968 domain-containing protein -
ER2796_RS08085 1626072..1626350 - 279 WP_012304870.1 hypothetical protein -
ER2796_RS08090 1626417..1626668 - 252 WP_000980994.1 hypothetical protein -
ER2796_RS08095 1626885..1627040 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ER2796_RS08100 1627112..1627399 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ER2796_RS08105 1627399..1627638 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ER2796_RS23485 1627663..1627968 + 306 WP_001326990.1 hypothetical protein -
ER2796_RS08110 1628171..1628503 + 333 WP_001301033.1 protein FlxA -
ER2796_RS22760 1628940..1629089 - 150 WP_011443592.1 hypothetical protein -
ER2796_RS08115 1629124..1629402 - 279 Protein_1549 hypothetical protein -
ER2796_RS08120 1629386..1629616 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
ER2796_RS08125 1629700..1630107 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
ER2796_RS08130 1630274..1630429 + 156 WP_000379575.1 DUF1391 family protein -
ER2796_RS08135 1630589..1630807 + 219 WP_038432574.1 hypothetical protein -
ER2796_RS08145 1631375..1631563 + 189 WP_000854559.1 cell division inhibition protein DicB -
ER2796_RS08150 1631560..1631751 + 192 WP_038432577.1 lysis protein YdfD -
ER2796_RS23500 1631844..1632611 + 768 Protein_1556 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1611430..1634474 23044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T49364 WP_000323025.1 NZ_CP009644:c1627399-1627112 [Escherichia coli ER2796]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T49364 NZ_CP009644:c1627399-1627112 [Escherichia coli ER2796]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT49364 WP_000534858.1 NZ_CP009644:c1627638-1627399 [Escherichia coli ER2796]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT49364 NZ_CP009644:c1627638-1627399 [Escherichia coli ER2796]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References