157132

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1532908..1533434 Replicon chromosome
Accession NZ_CP053605
Organism Escherichia coli strain NEB_Turbo

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HO393_RS07455 Protein ID WP_000323025.1
Coordinates 1532908..1533195 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HO393_RS07460 Protein ID WP_000534858.1
Coordinates 1533195..1533434 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO393_RS07410 1527932..1528147 - 216 WP_000839590.1 phage lysis protein EssD -
HO393_RS07415 1528901..1529116 - 216 WP_000066484.1 cold shock-like protein CspB -
HO393_RS07420 1529417..1529629 + 213 WP_000087756.1 cold shock-like protein CspF -
HO393_RS07425 1529684..1529773 + 90 WP_120795389.1 hypothetical protein -
HO393_RS07430 1530051..1530803 - 753 WP_001047135.1 antitermination protein -
HO393_RS07435 1530817..1531866 - 1050 WP_001265198.1 DUF968 domain-containing protein -
HO393_RS07440 1531868..1532146 - 279 WP_012304870.1 hypothetical protein -
HO393_RS07445 1532213..1532464 - 252 WP_000980994.1 hypothetical protein -
HO393_RS07450 1532681..1532836 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HO393_RS07455 1532908..1533195 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HO393_RS07460 1533195..1533434 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HO393_RS07465 1533459..1533764 + 306 WP_001326990.1 hypothetical protein -
HO393_RS07470 1533967..1534299 + 333 WP_001301033.1 protein FlxA -
HO393_RS07475 1534736..1534885 - 150 WP_011443592.1 hypothetical protein -
HO393_RS07480 1534920..1535198 - 279 Protein_1460 hypothetical protein -
HO393_RS07485 1535182..1535412 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
HO393_RS07490 1535496..1535903 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
HO393_RS07495 1536070..1536225 + 156 WP_000379575.1 DUF1391 family protein -
HO393_RS07500 1536385..1536603 + 219 WP_001171942.1 hypothetical protein -
HO393_RS07505 1536607..1536771 - 165 WP_014639039.1 hypothetical protein -
HO393_RS07510 1537171..1537359 + 189 WP_000854559.1 cell division inhibition protein DicB -
HO393_RS07515 1537356..1537547 + 192 WP_001083297.1 lysis protein YdfD -
HO393_RS07520 1537640..1538407 + 768 Protein_1468 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1517365..1540270 22905


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T157132 WP_000323025.1 NZ_CP053605:c1533195-1532908 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T157132 NZ_CP069077:366541-366843 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT157132 WP_000534858.1 NZ_CP053605:c1533434-1533195 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT157132 NZ_CP069077:366891-367112 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References