137571

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2238804..2239330 Replicon chromosome
Accession NZ_CP043193
Organism Escherichia coli O16:H48 strain PG20180063

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FYA14_RS10845 Protein ID WP_000323025.1
Coordinates 2239043..2239330 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FYA14_RS10840 Protein ID WP_000534858.1
Coordinates 2238804..2239043 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA14_RS10780 2233831..2234598 - 768 Protein_2099 exonuclease -
FYA14_RS10785 2234691..2234882 - 192 WP_001083297.1 lysis protein YdfD -
FYA14_RS10790 2234879..2235067 - 189 WP_000854559.1 cell division inhibition protein DicB -
FYA14_RS10800 2235635..2235853 - 219 WP_001171942.1 hypothetical protein -
FYA14_RS10805 2236013..2236168 - 156 WP_000379575.1 DUF1391 family protein -
FYA14_RS10810 2236335..2236742 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FYA14_RS10815 2236826..2237056 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
FYA14_RS10820 2237040..2237318 + 279 Protein_2106 hypothetical protein -
FYA14_RS10825 2237353..2237502 + 150 WP_011443592.1 hypothetical protein -
FYA14_RS10830 2237939..2238271 - 333 WP_001301033.1 protein FlxA -
FYA14_RS10835 2238474..2238779 - 306 WP_001326990.1 hypothetical protein -
FYA14_RS10840 2238804..2239043 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FYA14_RS10845 2239043..2239330 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FYA14_RS10850 2239402..2239557 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FYA14_RS10855 2239774..2240025 + 252 WP_000980994.1 hypothetical protein -
FYA14_RS10860 2240092..2240370 + 279 WP_012304870.1 hypothetical protein -
FYA14_RS10865 2240372..2241421 + 1050 WP_001265198.1 DUF968 domain-containing protein -
FYA14_RS10870 2241435..2242187 + 753 WP_001047135.1 antitermination protein -
FYA14_RS10875 2242465..2242554 - 90 WP_120795389.1 hypothetical protein -
FYA14_RS10880 2242609..2242821 - 213 WP_000087756.1 cold shock-like protein CspF -
FYA14_RS10885 2243122..2243337 + 216 WP_000066484.1 cold shock-like protein CspB -
FYA14_RS23365 2243701..2243871 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
FYA14_RS10890 2244091..2244306 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2226806..2253674 26868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T137571 WP_000323025.1 NZ_CP043193:2239043-2239330 [Escherichia coli O16:H48]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T137571 NZ_CP043193:2239043-2239330 [Escherichia coli O16:H48]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT137571 WP_000534858.1 NZ_CP043193:2238804-2239043 [Escherichia coli O16:H48]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT137571 NZ_CP056830:c2690601-2690335 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References